ArticleJournal of clinical lipidology
Changes in truncal obesity and fat distribution predict arterial health.
Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Abdominal obesity and digestive system cancer: a systematic review and meta-analysis of prospective studies.BMC public health · 2023Pooled it
- Evolution of Postpartum Weight and Body Composition after Excessive Gestational Weight Gain: The Role of Lifestyle Behaviors-Data from the INTER-ACT Control Group.International journal of environmental research and public health · 2021Trial
- Effects of an Aqueous Extract ofNutrients · 2018Trial
- Restless legs syndrome, periodic limb movements of sleep, and subclinical cardiovascular disease.Sleep and biological rhythms · 2024Article
- Noninvasive central hemodynamic monitoring in the primary care setting: improving prevention and management of cardiovascular diseases.Journal of clinical and translational research · 2023Article
- Anthropometric measurements and their association with endothelial function and arterial stiffness of eutrophic individuals and with overweight.Archives of endocrinology and metabolism · 2023Article
- The association between baseline circulating progenitor cells and vascular function: The role of aging and risk factors.Vascular medicine (London, England) · 2022Article
- Fat-Free Mass Index, Visceral Fat Level, and Muscle Mass Percentage Better Explain Deviations From the Expected Value of Aortic Pressure and Structural and Functional Arterial Properties Than Body Fat Indexes.Frontiers in nutrition · 2022Article
- Association of the Gut Microbiota with Weight-Loss Response within a Retail Weight-Management Program.Microorganisms · 2020Article
- A cardiovascular disease risk factor in children with congenital heart disease: unmasking elevated waist circumference - a CHAMPS* study *CHAMPS: Children's Healthy-Heart Activity Monitoring Program in Saskatchewan.BMC cardiovascular disorders · 2020Article
- Waist Circumference and Risk of Liver Cancer: A Systematic Review and Meta-Analysis of over 2 Million Cohort Study Participants.Liver cancer · 2020Review
- Arterial Stiffness Parameters Correlate with Estimated Cardiovascular Risk in Humans: A Clinical Study.International journal of environmental research and public health · 2019Article
- Influence of Body Composition on Arterial Stiffness in Middle-Aged Adults: Healthy UAL Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2019Article
- Android Fat Deposition and Its Association With Cardiovascular Risk Factors in Overweight Young Males.Frontiers in physiology · 2019Article
- Correlations between the abdominal fat-related parameters and severity of coronary artery disease assessed by computed tomography.Quantitative imaging in medicine and surgery · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTruncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function.
objectiveWe assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function.
methodsWe recruited 711 healthy volunteers (235 males, age 48 ± 11 years) into the Emory Predictive Health Study; 498 returned at 1 year. Measurements included anthropometric and chemistry panels, fat mass using dual-energy X-ray absorptiometry, arterial stiffness indices (pulse wave velocity [PWV], augmentation index [AIx], and subendocardial viability ratio [SEVR]; Sphygmocor), flow-mediated dilation (FMD), and reactive hyperemia index (Endo-PAT).
resultsAt baseline, measures of body mass correlated with PWV, AIx, SEVR, and FMD. In a multivariable analysis including body mass index (BMI) and traditional risk factors, BMI remained an independent predictor of PWV, AIx, SEVR, and FMD. In a model including BMI and measures of fat distribution, android fat remained an independent predictor of PWV (β = 0.31, P = .004), AIx (β = 0.24, P = .008), and SEVR (β = -0.41, P < .001). The 1-year change in android fat correlated negatively with change in SEVR (β = -0.13, P = .005) and FMD (β = -0.13, P = .006) after adjustment for change in gynoid fat.
conclusionIn addition to BMI, android fat is a determinant of arterial stiffness, independent of traditional risk factors. Changes in android fat over time are associated with simultaneous changes in vascular function, indicating fat distribution's effect on vascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.