Evidence map›Paper›PMID 28951609›Full record

ReviewNature reviews. Neuroscience2017

Rehabilitating the addicted brain with transcranial magnetic stimulation.

Marco Diana, Tommi Raij, Miriam Melis, Aapo Nummenmaa, Lorenzo Leggio, Antonello Bonci

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06739304 (The Effectiveness of Mindfulness-based Relapse Prevention), which is not on this map. Cited by 119 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 8 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06739304 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effectiveness of Mindfulness-based Relapse Prevention: A Randomized Controlled Trial Study

TypeinterventionalSponsorSir Run Run Shaw HospitalRan2023 to 2023Enrolled1,200ConditionsSubstance Use DisorderArmsMindfulness-based Relapse Prevention
3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 8 syntheses or guidelines pooled it, 222 citations in OpenAlex.

  1. Pooled it
  2. Effect of non-invasive brain stimulation on conscious disorder in patients after brain injury: a network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  3. Pooled it
  4. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
    Pooled it
  5. Pooled it
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  9. Trial
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  15. Article
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  19. Abnormal ventromedial-to-dorsolateral hierarchical topography of striatal circuits in cocaine use disorder and its modulations by brain stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Marco Diana'G. Minardi' Laboratory for Cognitive Neuroscience, Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Tommi RaijShirley Ryan AbilityLab, Center for Brain Stimulation, the Department of Physical Medicine and Rehabilitation and the Department of Neurobiology, Northwestern University, Chicago, Illinois 60611, USA.
Miriam MelisDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.
Aapo NummenmaaMassachusetts General Hospital (MGH)/Massachusetts Institute of Technology (MIT)/Harvard Medical School (HMS) Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, Massachusetts 02129, USA.
Lorenzo LeggioSection on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, US National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research (NIAAA DICBR) and US National Institute on Drug Abuse Intramural Research Program (NIDA IRP), NIH (National Institutes of Health), Bethesda, Maryland 20892, USA; and at the Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA.
Antonello BonciUS National Institute on Drug Abuse Intramural Research Program (NIDA IRP); and at the Departments of Neuroscience and Psychiatry, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Brown University · USHarvard University · USNational Institute on Drug Abuse · USShirley Ryan AbilityLab · USUniversity of Cagliari · ITUniversity of Sassari · IT

Funding

Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIAAA000218 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LEGGIO, LORENZO · 2013 to 2020
$22.8M
Modeling TMS-induced Cortical Network ActivityR00EB015445 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI NUMMENMAA, AAPO · 2015 to 2017
$747k
MRI-navigated 3-channel TMS with 64-channel EEG instrumentS10OD020080 · OD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI GRAFMAN, JORDAN HENRY · 2015 to 2015
$584k
6 · The paper itself

Abstract

Substance use disorders (SUDs) are one of the leading causes of morbidity and mortality worldwide. In spite of considerable advances in understanding the neural underpinnings of SUDs, therapeutic options remain limited. Recent studies have highlighted the potential of transcranial magnetic stimulation (TMS) as an innovative, safe and cost-effective treatment for some SUDs. Repetitive TMS (rTMS) influences neural activity in the short and long term by mechanisms involving neuroplasticity both locally, under the stimulating coil, and at the network level, throughout the brain. The long-term neurophysiological changes induced by rTMS have the potential to affect behaviours relating to drug craving, intake and relapse. Here, we review TMS mechanisms and evidence that rTMS is opening new avenues in addiction treatments.

Indexed as

Behavior, AddictiveBrainHumansNeuronal PlasticitySubstance-Related DisordersTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID28951609
OpenAlexW2760617544

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.