Evidence map›Paper›PMID 28972187›Full record

ArticleThe Journal of biological chemistry2017

Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo- and endocytosis.

Cecilia Brännmark, William Lövfors, Ali M Komai, Tom Axelsson, Mickaël F El Hachmane, Saliha Musovic, Alexandra Paul, Elin Nyman, Charlotta S Olofsson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Cecilia BrännmarkDepartment of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg.
William LövforsDepartments of Biomedical Engineering, SE-581 83 Linköping; Mathematics, Linköping University, SE-581 83 Linköping.
Ali M KomaiDepartment of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg.
Tom AxelssonDepartments of Biomedical Engineering, SE-581 83 Linköping.
Mickaël F El HachmaneDepartment of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg.
Saliha MusovicDepartment of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg.
Alexandra PaulDepartment of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10 SE-412 96 Göteborg.
Elin NymanDepartments of Biomedical Engineering, SE-581 83 Linköping; Cardiovascular and Metabolic Diseases iMed Biotech Unit, AstraZeneca R&D, 431 83 Gothenburg, Sweden. Electronic address: elin.nyman@liu.se.
Charlotta S OlofssonDepartment of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Medicinaregatan 11, SE-405 30 Göteborg. Electronic address: charlotta.olofsson@gu.se.
University of Gothenburg · SELinköping University · SEChalmers University of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin is a hormone secreted from white adipocytes and takes part in the regulation of several metabolic processes. Although the pathophysiological importance of adiponectin has been thoroughly investigated, the mechanisms controlling its release are only partly understood. We have recently shown that adiponectin is secreted via regulated exocytosis of adiponectin-containing vesicles, that adiponectin exocytosis is stimulated by cAMP-dependent mechanisms, and that Ca

Indexed as

3T3-L1 CellsAdenosine MonophosphateAdenosine TriphosphateAdipocytes, WhiteAdiponectinAnimalsBiological TransportCalciumElectric CapacitanceEndocytosisExocytosisKineticsMiceModels, TheoreticalTransport VesiclesAdenosine MonophosphateAdenosine TriphosphateAdiponectinAdipoq protein, mouseCalciumadipocyteadipokineadiponectinelectrophysiologyendocytosisexocytosismathematical modeling

Identifiers

PMID28972187
PMCPMC5723991
OpenAlexW2762848444

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.