Evidence map›Paper›PMID 28974581›Full record

ArticleThe Journal of biological chemistry2017

Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of G

Stanley M Kanai, Alethia J Edwards, Joel G Rurik, Patrick Osei-Owusu, Kendall J Blumer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. A Building Block Approach for the Total Synthesis of YM-385781.European journal of organic chemistry · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stanley M KanaiFrom the Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110 and.ORCID 0000-0001-9074-0624
Alethia J EdwardsDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102.
Joel G RurikFrom the Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110 and.
Patrick Osei-OwusuDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102.
Kendall J BlumerFrom the Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110 and kblumer@wustl.edu.
Washington University in St. Louis · USDrexel University · US

Funding

MECHANISM &REGULATION OF RECEPTOR G PROTEIN SIGNALINGR01GM044592 · NIGMS · WASHINGTON UNIVERSITY · PI BLUMER, KENDALL J · 1990 to 2017
$7.5M
RGS PROTEIN FUNCTION AND REGULATIONR01HL075632 · NHLBI · WASHINGTON UNIVERSITY · PI BLUMER, KENDALL J · 2005 to 2013
$4.5M
Expanding Access to Planar Illumination Microscopy in a Neuroimaging CoreR24NS086741 · NINDS · WASHINGTON UNIVERSITY · PI TAGHERT, PAUL H · 2014 to 2017
$814k
NHLBI NIH HHS R01 HL075632NIGMS NIH HHS R01 GM044592NINDS NIH HHS R24 NS086741
6 · The paper itself

Abstract

Regulator of G protein signaling 2 (RGS2) controls signaling by receptors coupled to the G

Indexed as

AnimalsCells, CulturedGTP-Binding Protein alpha Subunits, Gq-G11MaleMesenteric ArteriesMiceMice, Inbred C57BLMice, KnockoutMuscle ContractionProtein BindingProteolysisRGS ProteinsSignal TransductionGTP-Binding Protein alpha Subunits, Gq-G11Rgs2 protein, mouseRGS ProteinscalciumG proteinproteasomeregulator of G protein signaling (RGS)ubiquitinubiquitinationubiquitylationvascular biologyvascular smooth muscle cells;

Identifiers

PMID28974581
PMCPMC5702667
OpenAlexW2761066485

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.