Observational studyClinical medicine (London, England)2017
Statin therapy in patients with community-acquired pneumonia.
Observational study in Clinical medicine (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis.Pharmacological reports : PR · 2021Pooled it
- Reducing the complications from community acquired pneumonia: a review.Journal of thoracic disease · 2026Review
- Impact of Long-Term Statin Therapy on Incidence and Severity of Community-Acquired Pneumonia: A Real-World Data Analysis.Biomedicines · 2025Article
- The Association Between Statin Therapy and the Subsequent Clinical Course of Patients With Melioidosis.Journal of tropical medicine · 2025Article
- Repositioning of HMG-CoA Reductase Inhibitors as Adjuvants in the Modulation of Efflux Pump-Mediated Bacterial and Tumor Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Phenotypical and Functional Alteration of γδ T Lymphocytes in COVID-19 Patients: Reversal by Statins.Cells · 2022Article
- Prognostic Value of Decreased High-Density Lipoprotein Cholesterol Levels in Infective Endocarditis.Journal of clinical medicine · 2022Article
- Statins and Bempedoic Acid: Different Actions of Cholesterol Inhibitors on Macrophage Activation.International journal of molecular sciences · 2021Article
- Persistence of Lipoproteins and Cholesterol Alterations after Sepsis: Implication for Atherosclerosis Progression.International journal of molecular sciences · 2021Review
- Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19.Nature communications · 2021Article
- Triggering of cardiovascular disease by infection type: The Atherosclerosis Risk in Communities study (ARIC).International journal of cardiology · 2021Article
- Article
- New Pharmacological Tools to Target Leukocyte Trafficking in Lung Disease.Frontiers in immunology · 2021Review
- Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK.Atherosclerosis · 2020Review
- Association Between Antecedent Statin Use and Decreased Mortality in Hospitalized Patients with COVID-19.Research square · 2020Article
- Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Hypoxia-Inducible Factor-1: A Potential Target to Treat Acute Lung Injury.Oxidative medicine and cellular longevity · 2020Review
- Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study.International journal of environmental research and public health · 2019Article
- Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions.Biogerontology · 2018Review
- Advances in community-acquired pneumonia.Therapeutic advances in infectious diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. There is evidence of an association between improved survival from infection and statin use. The possible beneficial effects of statins are complicated by the common use of macrolide antibiotics for pneumonia, with current guidance suggesting that concurrent macrolide and statin use is contraindicated.We conducted an observational study of statin use in patients with CAP. Of 2,067 patients with CAP, 30.4% were on statin therapy at admission. Statin users were more likely to survive the admission (p<0.001). In addition, we conducted a survey of doctors and found that knowledge regarding concurrent macrolide and statin use was lacking.These data suggest a potential role of statins in the management of CAP. Further research using high-dose statins is required to assess their safe use in subjects with mild to moderate infections.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.