Evidence map›Paper›PMID 28974616›Full record

ArticlemBio2017

Murine Cytomegalovirus Spreads by Dendritic Cell Recirculation.

Helen E Farrell, Kimberley Bruce, Clara Lawler, Martha Oliveira, Rhonda Cardin, Nicholas Davis-Poynter, Philip G Stevenson

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024
    Review
  9. Article
  10. Article
  11. Oncolytic α-herpesvirus and myeloid-tropic cytomegalovirus cooperatively enhance systemic antitumor responses.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. CD4Journal of virology · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Helen E FarrellSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia h.farrell1@uq.edu.au.ORCID 0000-0002-7214-2767
Kimberley BruceSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.
Clara LawlerSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.
Martha OliveiraSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.
Rhonda CardinPathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
Nicholas Davis-PoynterSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.
Philip G StevensonSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia.ORCID 0000-0002-3520-5060
The University of Queensland · AULouisiana State University · US

Funding

Role of Viral Chemokine Receptors in Cytomegalovirus Latency.R01AI087683 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI CARDIN, RHONDA D · 2012 to 2015
$1.4M
NIAID NIH HHS R01 AI087683
6 · The paper itself

Abstract

Herpesviruses have coevolved with their hosts over hundreds of millions of years and exploit fundamental features of their biology. Cytomegaloviruses (CMVs) colonize blood-borne myeloid cells, and it has been hypothesized that systemic dissemination arises from infected stem cells in bone marrow. However, poor CMV transfer by stem cell transplantation argues against this being the main reservoir. To identify alternative pathways for CMV spread, we tracked murine CMV (MCMV) colonization after mucosal entry. We show that following intranasal MCMV infection, lung CD11c

Indexed as

AnimalsDendritic CellsHerpesviridae InfectionsHost-Pathogen InteractionsHumansLungLymph NodesMiceMice, Inbred BALB CMuromegalovirusReceptors, ChemokineSalivary GlandsViremiaVirus ReplicationReceptors, Chemokinechemokine receptorscytomegalovirusdendritic cellsvirus-host interactions

Identifiers

PMID28974616
PMCPMC5626969
OpenAlexW2763071660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.