Evidence map›Paper›PMID 28978712›Full record

ArticleJournal of virology2017

Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication.

H Jacques Garrigues, Kellie Howard, Serge Barcy, Minako Ikoma, Ashlee V Moses, Gail H Deutsch, David Wu, Keiji Ueda, Timothy M Rose

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Molecular Mechanisms of KSHV Latency Establishment and Maintenance.Current clinical microbiology reports · 2024
    Article
  6. Article
  7. Article
  8. Lack of CD8Oncotarget · 2020
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

H Jacques GarriguesCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Kellie HowardCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Serge BarcyCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Minako IkomaCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Ashlee V MosesVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.ORCID http://orcid.org/0000-0001-5017-0735
Gail H DeutschPathology, Seattle Children's Hospital, Seattle, Washington, USA.
David WuDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Keiji UedaDivision of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Timothy M RoseCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA timothy.rose@seattlechildrens.org.
Infectious Disease Research Institute · USOregon Health & Science University · USSeattle Children's Hospital · USThe University of Osaka · JPUniversity of Washington · US

Funding

Oral pathogenesis and host interactions of KSHV infection (P01 Parent Level)P01DE021954 · NIDCR · SEATTLE CHILDREN'S HOSPITAL · PI ROSE, TIMOTHY M · 2011 to 2015
$7.7M
Viral and cellular factors involved in KSHV entry in cells of the oral mucosaR01DE018927 · NIDCR · UNIVERSITY OF WASHINGTON · PI ROSE, TIMOTHY M · 2007 to 2011
$2.1M
NIDCR NIH HHS P01 DE021954NIDCR NIH HHS R01 DE018927
6 · The paper itself

Abstract

The latency-associated nuclear antigen (LANA) of the Kaposi's sarcoma-associated herpesvirus (KSHV) performs a variety of functions to establish and maintain KSHV latency. During latency, LANA localizes to discrete punctate spots in the nucleus, where it tethers viral episomes to cellular chromatin and interacts with nuclear components to regulate cellular and viral gene expression. Using highly sensitive tyramide signal amplification, we determined that LANA localizes to the cytoplasm in different cell types undergoing the lytic cycle of replication after

Indexed as

Virus ReplicationAnimalsAntigens, ViralCell LineChlorocebus aethiopsCytoplasmHerpesvirus 8, HumanHumansImmediate-Early ProteinsMass SpectrometryNuclear ProteinsProtein IsoformsSarcoma, KaposiVero CellsVirus LatencyAntigens, ViralImmediate-Early Proteinslatency-associated nuclear antigenNuclear ProteinsProtein IsoformsactivationcytoplasmKSHVLANAmass spectrometrymigrationviral replication

Identifiers

PMID28978712
PMCPMC5709576
OpenAlexW2764208338

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.