ArticleMolecular biology and evolution2017
Selective Constraints on Coding Sequences of Nervous System Genes Are a Major Determinant of Duplicate Gene Retention in Vertebrates.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Evolutionary dynamics of the arthropod molting machinery.Molecular biology and evolution · 2026Review
- Dynamics of Expression Variability Contribute to Retention of Small-Scale vs. Whole-Genome Duplicates.Genome biology and evolution · 2026Article
- Accurate Inference of the Polyploid Continuum Using Forward-Time Simulations.Molecular biology and evolution · 2024Article
- Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings.Molecular psychiatry · 2024Article
- Dosage sensitivity shapes balanced expression and gene longevity of homoeologs after whole-genome duplications in angiosperms.The Plant cell · 2024Article
- Gene Function is a Driver of Activin Signaling Pathway Evolution Following Whole-Genome Duplication in Rainbow Trout (Oncorhynchus mykiss).Genome biology and evolution · 2024Article
- Expectations of duplicate gene retention under the gene duplicability hypothesis.BMC ecology and evolution · 2023Article
- Article
- Dosage balance acts as a time-dependent selective barrier to subfunctionalization.BMC ecology and evolution · 2023Article
- Promoter evolution of mammalian gene duplicates.BMC biology · 2023Article
- WGDTree: a phylogenetic software tool to examine conditional probabilities of retention following whole genome duplication events.BMC bioinformatics · 2022Article
- Parallel evolution of amphioxus and vertebrate small-scale gene duplications.Genome biology · 2022Article
- Zebrafish excel in number discrimination under an operant conditioning paradigm.Animal cognition · 2022Article
- The divergence of alternative splicing between ohnologs in teleost fishes.BMC ecology and evolution · 2021Article
- Region-specific expression of young small-scale duplications in the human central nervous system.BMC ecology and evolution · 2021Article
- Comparative regulomics supports pervasive selection on gene dosage following whole genome duplication.Genome biology · 2021Article
- Robust inference of positive selection on regulatory sequences in the human brain.Science advances · 2020Article
- Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors.Molecular biology and evolution · 2020Article
- OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates.Nucleic acids research · 2020Article
- Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The evolutionary history of vertebrates is marked by three ancient whole-genome duplications: two successive rounds in the ancestor of vertebrates, and a third one specific to teleost fishes. Biased loss of most duplicates enriched the genome for specific genes, such as slow evolving genes, but this selective retention process is not well understood. To understand what drives the long-term preservation of duplicate genes, we characterized duplicated genes in terms of their expression patterns. We used a new method of expression enrichment analysis, TopAnat, applied to in situ hybridization data from thousands of genes from zebrafish and mouse. We showed that the presence of expression in the nervous system is a good predictor of a higher rate of retention of duplicate genes after whole-genome duplication. Further analyses suggest that purifying selection against the toxic effects of misfolded or misinteracting proteins, which is particularly strong in nonrenewing neural tissues, likely constrains the evolution of coding sequences of nervous system genes, leading indirectly to the preservation of duplicate genes after whole-genome duplication. Whole-genome duplications thus greatly contributed to the expansion of the toolkit of genes available for the evolution of profound novelties of the nervous system at the base of the vertebrate radiation.
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