Evidence map›Paper›PMID 28982599›Full record

ArticleFree radical biology & medicine2017

Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice.

Jarrod A Call, Jean Donet, Kyle S Martin, Ashish K Sharma, Xiaobin Chen, Jiuzhi Zhang, Jie Cai, Carolina A Galarreta, Mitsuharu Okutsu, Zhongmin Du and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Jarrod A CallCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Departments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Jean DonetCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Departments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Kyle S MartinDepartments of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Ashish K SharmaDepartments of Surgery, University of Virginia, Charlottesville, VA 22908, USA.
Xiaobin ChenCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Department of Cardiology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China.
Jiuzhi ZhangCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Department of Critical Care Medicine and Institute of Critical Care Medicine, First Affiliate Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, Liaoning Province 116011, China.
Jie CaiCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Department of Infectious Disease, First Affiliate Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province 210029, China.
Carolina A GalarretaDepartments of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA.
Mitsuharu OkutsuCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Departments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Zhongmin DuDepartments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Vitor A LiraCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Departments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Mei ZhangCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Departments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Borna MehradDepartments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Brian H AnnexDepartments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Alexander L KlibanovDepartments of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Russell P BowlerDivision of Pulmonary Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Victor E LaubachDepartments of Surgery, University of Virginia, Charlottesville, VA 22908, USA.
Shayn M PeirceDepartments of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Zhen YanCenter for Skeletal Muscle Research at Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA; Departments of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Departments of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA; Departments of Molecular Physiology & Biological Physics, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: zhen.yan@virginia.edu.
University of Virginia · USDalian Medical University · CNNational Jewish Health · USXiangya Hospital Central South University · CN

Funding

Muscle-mediated protection against MODSR01GM114840 · NIGMS · UNIVERSITY OF VIRGINIA · PI YAN, ZHEN · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM114840
6 · The paper itself

Abstract

Multiple organ dysfunction syndrome (MODS) is a detrimental clinical complication in critically ill patients with high mortality. Emerging evidence suggests that oxidative stress and endothelial activation (induced expression of adhesion molecules) of vital organ vasculatures are key, early steps in the pathogenesis. We aimed to ascertain the role and mechanism(s) of enhanced extracellular superoxide dismutase (EcSOD) expression in skeletal muscle in protection against MODS induced by endotoxemia. We showed that EcSOD overexpressed in skeletal muscle-specific transgenic mice (TG) redistributes to other peripheral organs through the circulation and enriches at the endothelium of the vasculatures. TG mice are resistant to endotoxemia (induced by lipopolysaccharide [LPS] injection) in developing MODS with significantly reduced mortality and organ damages compared with the wild type littermates (WT). Heterogenic parabiosis between TG and WT mice conferred a significant protection to WT mice, whereas mice with R213G knock-in mutation, a human single nucleotide polymorphism leading to reduced binding EcSOD in peripheral organs, exacerbated the organ damages. Mechanistically, EcSOD inhibits vascular cell adhesion molecule 1 expression and inflammatory leukocyte adhesion to the vascular wall of vital organs, blocking an early step of the pathology in organ damage under endotoxemia. Therefore, enhanced expression of EcSOD in skeletal muscle profoundly protects against MODS by inhibiting endothelial activation and inflammatory cell adhesion, which could be a promising therapy for MODS.

Indexed as

AnimalsDisease Models, AnimalEndotoxemiaHumansMiceMice, TransgenicMultiple Organ FailureMuscle ProteinsMuscle, SkeletalSuperoxide DismutaseMuscle ProteinsSod3 protein, mouseSuperoxide DismutaseEcSODEndothelial activationEndotoxemiaFree radicalsMODSOxidative stressParabiosisSkeletal muscleVCAM-1

Identifiers

PMID28982599
PMCPMC5740866
OpenAlexW2761085207

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.