Evidence map›Paper›PMID 28982976›Full record

ArticleThe Journal of biological chemistry2017

Activation of the phospholipid scramblase TMEM16F by nanosecond pulsed electric fields (nsPEF) facilitates its diverse cytophysiological effects.

Claudia Muratori, Andrei G Pakhomov, Elena Gianulis, Jade Meads, Maura Casciola, Peter A Mollica, Olga N Pakhomova

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  12. Review
  13. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
  16. 5 ns electric pulses induce CaBioelectrochemistry (Amsterdam, Netherlands) · 2021
    Article
  17. Article
  18. 10 ns PEFs induce a histological response linked to cell death and cytotoxic T-lymphocytes in an immunocompetent mouse model of peritoneal metastasis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Claudia MuratoriFrom the Frank Reidy Research Center for Bioelectrics, and cmurator@odu.edu.
Andrei G PakhomovFrom the Frank Reidy Research Center for Bioelectrics, and.
Elena GianulisFrom the Frank Reidy Research Center for Bioelectrics, and.
Jade MeadsFrom the Frank Reidy Research Center for Bioelectrics, and.
Maura CasciolaFrom the Frank Reidy Research Center for Bioelectrics, and.
Peter A Mollicathe Department of Medical Diagnostics and Translational Sciences, Old Dominion University, Norfolk, Virginia 23508.
Olga N PakhomovaFrom the Frank Reidy Research Center for Bioelectrics, and.
BioElectronics (United States) · USOld Dominion University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanosecond pulsed electric fields (nsPEF) are emerging as a novel modality for cell stimulation and tissue ablation. However, the downstream protein effectors responsible for nsPEF bioeffects remain to be established. Here we demonstrate that nsPEF activate TMEM16F (or Anoctamin 6), a protein functioning as a Ca

Indexed as

ElectricityNanotechnologyAnoctaminsApoptosisCalciumCell MembraneDose-Response Relationship, RadiationHEK293 CellsHumansIon ChannelsPhosphatidylserinesPhospholipid Transfer ProteinsANO6 protein, humanAnoctaminsCalciumIon ChannelsPhosphatidylserinesPhospholipid Transfer ProteinsAnoctamin 6cell deathchloride channelelectroporationnanosecond pulsed electric fields (nsPEF)phosphatidylserineplasma membraneTMEM16F

Identifiers

PMID28982976
PMCPMC5702676
OpenAlexW2762883849

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.