Evidence map›Paper›PMID 28985270›Full record

Trial reportAmerican journal of hypertension2017

Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.

Alwyn S Todd, Robert J Walker, Robert J MacGinley, Jaimon Kelly, Tony R Merriman, Tanya J Major, Richard J Johnson

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Alwyn S ToddMater Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Robert J WalkerDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Robert J MacGinleyDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Jaimon KellyDepartment of Dietetics, School of Allied Health Sciences, Griffith University, Gold Coast, Queensland, Australia.
Tony R MerrimanDepartment of Biochemistry University of Otago, Dunedin, New Zealand.
Tanya J MajorDepartment of Biochemistry University of Otago, Dunedin, New Zealand.
Richard J JohnsonDivision of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado, USA.
University of Otago · NZBond University · AUGriffith University · AUMonash University · AUUniversity of Colorado Anschutz Medical Campus · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

backgroundSubjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, moderating or contributing factor to the development of hypertension has not been fully evaluated and very few studies have reported interactions between sodium intake and serum uric acid.

methodsWe performed further analysis of our randomized controlled clinical trials (Australian New Zealand Clinical Trials Registry #12609000161224 and #12609000292279) designed to assess the effects of modifying sodium intake on concentrations of serum markers, including uric acid. Uric acid and other variables (including blood pressure, renin, and aldosterone) were measured at baseline and 4 weeks following the commencement of low (60 mmol/day), moderate (150 mmol/day), and high (200-250 mmol/day) dietary sodium intake.

resultsThe median aldosterone-to-renin ratio was 1.90 [pg/ml]/[pg/ml] (range 0.10-11.04). Serum uric acid fell significantly in both the moderate and high interventions compared to the low sodium intervention. This pattern of response occurred when all subjects were analyzed, and when normotensive or hypertensive subjects were analyzed alone.

conclusionsAlthough previously reported in hypertensive subjects, these data provide evidence in normotensive subjects of an interaction between dietary sodium intake and serum uric acid. As this interaction is present in the absence of hypertension, it is possible it could play a role in hypertension development, and will need to be considered in future trials of dietary sodium intake. CLINICAL TRIALS REGISTRATION: The trials were registered with the Australian and New Zealand Clinical Trials Registry as ACTRN12609000161224 and ACTRN1260.

Indexed as

AdultAgedAldosteroneBlood PressureDietDiet, Sodium-RestrictedFemaleHumansHypertensionMaleMiddle AgedReninRenin-Angiotensin SystemSodium, DietaryUric AcidAldosteroneReninSodium, DietaryUric Acidblood pressurehypertensionsodiumurateuric acid

Identifiers

PMID28985270
PMCPMC6248421
OpenAlexW2750805291

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.