ArticleNature reviews. Genetics2017
Convergence between biological, behavioural and genetic determinants of obesity.
Article in Nature reviews. Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 109 citations in OpenAlex.
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- Quorum quenching enzymes disrupt bacterial communication in a sex- and dose-dependent manner.Animal models and experimental medicine · 2025Article
- Considerations on efforts needed to improve our understanding of the genetics of obesity.International journal of obesity (2005) · 2025Review
- Editorial: Dietary influences on white and brown adipose tissue: mechanisms and health implications.Frontiers in nutrition · 2025Article
- Evaluation of the gastric microbiota based on body mass index using 16S rRNA gene sequencing.Frontiers in cellular and infection microbiology · 2025Article
- The Patient's Journey in Obesity within the United States: An Exercise of Resilience against Disease.Life (Basel, Switzerland) · 2024Review
- Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly.Scientific reports · 2024Article
- Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression.Nature communications · 2024Article
- Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity.International journal of obesity (2005) · 2024Article
- Dietary macronutrient composition impacts gene regulation in adipose tissue.Communications biology · 2024Article
- Hypothalamic GABAergic Neurons Expressing Cellular Retinoic Acid Binding Protein 1 (CRABP1) Are Sensitive to Metabolic Status and Liraglutide in Male Mice.Neuroendocrinology · 2024Article
- Traumatic Life Events, Violence, and Obesity: A Cross-Sectional Study from 408 Patients Enrolled in a Bariatric Surgery Program.Obesity facts · 2024Article
- An optimized method for gene knockdown in differentiating human and mouse adipocyte cultures.bioRxiv : the preprint server for biology · 2023Article
- Examining the risk factors for overweight and obesity among women in Ghana: A multilevel perspective.Heliyon · 2023Article
- Resting energy expenditure of a diverse group of South African men and women.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Article
- A Hybrid MCDM Approach Based on Fuzzy-Logic and DEMATEL to Evaluate Adult Obesity.International journal of environmental research and public health · 2022Article
- 'Out of sync': a qualitative investigation of patients' experiences of atrial fibrillation and perceptions of weight management.BMJ open · 2022Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple biological, behavioural and genetic determinants or correlates of obesity have been identified to date. Genome-wide association studies (GWAS) have contributed to the identification of more than 100 obesity-associated genetic variants, but their roles in causal processes leading to obesity remain largely unknown. Most variants are likely to have tissue-specific regulatory roles through joint contributions to biological pathways and networks, through changes in gene expression that influence quantitative traits, or through the regulation of the epigenome. The recent availability of large-scale functional genomics resources provides an opportunity to re-examine obesity GWAS data to begin elucidating the function of genetic variants. Interrogation of knockout mouse phenotype resources provides a further avenue to test for evidence of convergence between genetic variation and biological or behavioural determinants of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.