Evidence map›Paper›PMID 28992467›Full record

Trial reportAtherosclerosis2017

Effect of statin on arginine metabolites in treated HIV-infection.

Sahera Dirajlal-Fargo, Vanessa El Kamari, Abdus Sattar, Khurshid Alam, Nicholas Funderburg, Danielle Labbato, Lisa Pirro, Chris T Longenecker, Wai Hong Wilson, Grace A McComsey

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sahera Dirajlal-FargoUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA.
Vanessa El KamariCase Western Reserve University, Cleveland, OH, USA.
Abdus SattarCase Western Reserve University, Cleveland, OH, USA.
Khurshid AlamCase Western Reserve University, Cleveland, OH, USA.
Nicholas FunderburgOhio State University School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Columbus, OH, USA.
Danielle LabbatoUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA.
Lisa PirroUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA.
Chris T LongeneckerUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA.
Wai Hong WilsonCleveland Clinic, Cleveland, OH, USA.
Grace A McComseyUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA; Rainbow Babies and Children's Hospital, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA. Electronic address: Grace.mccomsey@case.edu.
University Hospitals of Cleveland · USCase Western Reserve University · USCleveland Clinic · USThe Ohio State University · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Inflammation, Heart and BoneR01NR012642 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2010 to 2014
$2.5M
Pericardial fat, inflammation, and structural heart disease in HIVK23HL123341 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LONGENECKER, CHRIS TODD · 2014 to 2018
$885k
Cardiovascular disease and inflammation in Ugandan children with HIVK23HD088295 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI DIRAJLAL-FARGO, SAHERA · 2016 to 2020
$799k
Dysregulated arginine metabolism in treated HIV infectionR56HL126539 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2014 to 2014
$792k
NCATS NIH HHS UL1 TR000439NHLBI NIH HHS K23 HL123341NHLBI NIH HHS R56 HL126539NIAID NIH HHS P30 AI036219NICHD NIH HHS K23 HD088295NINR NIH HHS R01 NR012642
6 · The paper itself

Abstract

BACKGROUND AND

aimsAsymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide and an independent risk factor for cardiovascular disease. We examined the effect of statin on ADMA in HIV + patients on stable ART, and whether such an effect contributes to the favorable changes on carotid intima media thickness.

methodsThis is a secondary analysis of SATURN-HIV, in which HIV + adults on stable ART with HIV-1 RNA< 1000 copies/mL and LDL-cholesterol <130 mg/dL were randomized to 10 mg daily rosuvastatin or placebo. Arginine metabolites, ADMA, and markers of inflammation were assessed at baseline and 48 weeks. Carotid intima media thickness (c-IMT) was measured at baseline, 48 and 96 weeks. Spearman correlations, and linear mixed-effect models were used to study relationships among variables.

resultsOverall, 79% were male, 68% African Americans, with a median age of 46 years. In the statin arm, no change in ADMA levels was observed at 48 weeks (0.70%), whereas a trend towards an increase in ADMA levels (23.78%) was observed in the placebo group (p = 0.06). Elevated baseline ADMA (highest tertile) was associated with a 0.04 mm increase in c-IMT (p = 0.03) after adjusting for statin and study duration. No interaction was seen between baseline ADMA and statin randomization on change in c-IMT (p = 0.21).

conclusionsIn HIV + subjects on ART, rosuvastatin suppressed the increase over time in ADMA levels. Elevated baseline levels of ADMA were associated with increases in c-IMT, regardless of statin assignment. The favorable effect of rosuvastatin on c-IMT appears to be independent of the arginine pathway.

Indexed as

AdultAnti-HIV AgentsArginineBiomarkersCarotid Artery DiseasesCarotid Intima-Media ThicknessChi-Square DistributionCholesterol, LDLDouble-Blind MethodFemaleHIV-1HIV InfectionsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInflammation MediatorsLinear ModelsAnti-HIV AgentsArginineBiomarkersCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsInflammation MediatorsN,N-dimethylarginineRNA, ViralRosuvastatin CalciumADMAArginineCardiovascular diseasesHIVInflammation

Identifiers

PMID28992467
PMCPMC5671899
OpenAlexW2756865305

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.