ArticleJournal of developmental origins of health and disease2018
Poor perinatal growth impairs baboon aortic windkessel function.
Article in Journal of developmental origins of health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course.GeroScience · 2024Article
- Cardiovascular consequences of maternal obesity throughout the lifespan in first generation sheep.PloS one · 2022Article
- Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest.Journal of developmental origins of health and disease · 2021Article
- Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction.Clinical science (London, England : 1979) · 2021Article
- Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging.Journal of developmental origins of health and disease · 2021Review
- Hypertension Programmed in Adult Hens by Isolated Effects of Developmental Hypoxia In Ovo.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post-natal offspring early life phenotype.Journal of medical primatology · 2019Article
- Antenatal Synthetic Glucocorticoid Exposure at Human Therapeutic Equivalent Doses Predisposes Middle-Age Male Offspring Baboons to an Obese Phenotype That Emerges With Aging.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Intrauterine growth restriction results in persistent vascular mismatch in adulthood.The Journal of physiology · 2018Article
- Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status.Journal of breath research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.