Evidence map›Paper›PMID 29020971›Full record

SynthesisNutrition journal2017

Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials.

Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Hong Ren, Huaidong Hu

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 12 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 12 syntheses or guidelines pooled it, 243 citations in OpenAlex.

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  6. Curcumin and Polycystic Ovary Syndrome: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Si QinDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, No.76, Linjiang Road, Chongqing, 400010, People's Republic of China.
Lifan HuangDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, No.76, Linjiang Road, Chongqing, 400010, People's Republic of China.
Jiaojiao GongDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, No.76, Linjiang Road, Chongqing, 400010, People's Republic of China.
Shasha ShenDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, No.76, Linjiang Road, Chongqing, 400010, People's Republic of China.
Juan HuangDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, No.76, Linjiang Road, Chongqing, 400010, People's Republic of China.
Hong RenDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Huaidong HuDepartment of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, No.76, Linjiang Road, Chongqing, 400010, People's Republic of China. huhuaidong@sina.com.
Dalian Medical University · CNChongqing Medical University · CNSecond Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia is an important and common cardiovascular risk factor in the general population. The lipid-lowering effects of turmeric and curcumin are unconfirmed. We performed a meta-analysis to assess the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD).

methodsA comprehensive literature search was conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases to identify randomized controlled trials (published as of November 2016) that assessed the effect of turmeric and curcumin on blood lipid levels including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was used to assess the effect.

resultsThe analysis included 7 eligible studies (649 patients). Turmeric and curcumin significantly reduced serum LDL-C (SMD = -0.340, 95% confidence interval [CI]: -0.530 to -0.150, P < 0.0001) and TG (SMD = -0.214, 95% CI: -0.369 to -0.059, P = 0.007) levels as compared to those in the control group. These may be effective in lowering serum TC levels in patients with metabolic syndrome (MetS, SMD = -0.934, 95% CI: -1.289 to -0.579, P < 0.0001), and turmeric extract could possibly have a greater effect on reducing serum TC levels (SMD = -0.584, 95% CI: -0.980 to -0.188, P = 0.004); however, the efficacy is yet to be confirmed. Serum HDL-C levels were not obviously improved. Turmeric and curcumin appeared safe, and no serious adverse events were reported in any of the included studies.

conclusionsTurmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs. Further research is required to resolve uncertainties related to dosage form, dose and medication frequency of curcumin.

Indexed as

PhytotherapyCardiovascular DiseasesCholesterol, HDLCholesterol, LDLCurcumaCurcuminHumansPlant PreparationsRandomized Controlled Trials as TopicRisk FactorsTriglyceridesCholesterol, HDLCholesterol, LDLCurcuminPlant PreparationsTriglyceridesCardiovascular riskCholesterolCurcuminMeta-analysisTriglyceridesTurmeric

Identifiers

PMID29020971
PMCPMC5637251
OpenAlexW2762357782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.