ArticleCell host & microbe2017
Epithelial-Cell-Derived Phospholipase A
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Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Dysbiosis-Associated Lysophosphatidic Acid Primes Immune Checkpoint Inhibitor-Induced Intestinal Barrier Dysfunction via the Lysophosphatidic Acid Receptor 2-Myosin Light Chain Kinase Axis.Cellular and molecular gastroenterology and hepatology · 2026Article
- Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection.Parasite immunology · 2026Article
- Secretory phospholipase ACommunications biology · 2025Article
- Secreted phospholipase A2 regulates intercellular communications by coordinating extracellular phospholipid metabolism.International immunology · 2025Review
- Hookworm infection modulates lung and intestinal transcriptomic responses to SARS-CoV-2 in Syrian hamsters.Frontiers in immunology · 2025Article
- Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024Review
- To die or not to die: Gasdermins in intestinal health and disease.Seminars in immunology · 2024Review
- Genomic Regions Associated with Resistance to Gastrointestinal Nematode Parasites in Sheep-A Review.Genes · 2024Review
- Inactivation of Group 1B Phospholipase AInternational journal of molecular sciences · 2023Article
- Targeting helminths: The expanding world of type 2 immune effector mechanisms.The Journal of experimental medicine · 2023Review
- Male-Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.PLoS pathogens · 2023Article
- Host genetic backgrounds: the key to determining parasite-host adaptation.Frontiers in cellular and infection microbiology · 2023Review
- Genome-Wide Association Study forPathogens (Basel, Switzerland) · 2022Article
- "Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity".Mucosal immunology · 2022Review
- Old but New: Group IIA Phospholipase AMetabolites · 2022Review
- Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.JCI insight · 2022Article
- The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.Frontiers in immunology · 2022Review
- Identification and expression of phospholipase A2 genes related to transcriptional control in the interleukin-17A/F1 pathway in the intestines of Japanese medakaFish and shellfish immunology reports · 2021Article
- Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.Science (New York, N.Y.) · 2021Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Lewis J EntwistleAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Victoria S PellyAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stephanie M CoomesAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Yashaswini KannanAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Jimena Perez-LloretAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stephanie CziesoAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Mariana Silva Dos SantosMetabolomics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
James I MacRaeMetabolomics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Lucy CollinsonElectron Microscopy, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Abdul SesayAdvanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nikolay NikolovAdvanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Amina MetidjiAhR Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Helena HelmbyDepartment of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
David Y HuiDepartment of Pathology, Metabolic Disease Research Center, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA.
Mark S WilsonAllergy and Anti-helminth Immunity Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Immunology Discovery, Genentech Inc., South San Francisco, CA 94080, USA. Electronic address: wilson.mark@gene.com.
The Francis Crick Institute · GBUniversity of Cincinnati Medical Center · USUniversity of London · GB
Funding
Intestinal LPC/LPA modulation of gut microbiota and metabolic diseaseR01DK112657 · NIDDK · UNIVERSITY OF CINCINNATI · PI HUI, DAVID YIU-KWAN · 2016 to 2020
$1.8MMedical Research Council MC_UP_A253_1028NIDDK NIH HHS R01 DK112657Wellcome Trust
Abstract
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A
Indexed as
Adaptive ImmunityAnimalsGastrointestinal MicrobiomeGroup IB Phospholipases A2Intestinal MucosaLarvaMiceMice, KnockoutNematospiroides dubiusNippostrongylusPhospholipidsPrimary Cell CultureStrongylida InfectionsGroup IB Phospholipases A2PhospholipidsPla2g1b protein, mouseanthelminticepithelial cellHeligmosomoides polygyrushelminthintestineNippostrongylus brasiliensisPhosphatidylethanolaminephospholipasePLA(2)g1BRNA-seq
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.