Evidence map›Paper›PMID 29027245›Full record

ArticleClinical and experimental pharmacology & physiology2018

Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.

Haseeb Valli, Shiraz Ahmad, Sujan Sriharan, Lydia D Dean, Andrew A Grace, Kamalan Jeevaratnam, Hugh R Matthews, Christopher L-H Huang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental pharmacology & physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  5. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
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  11. Finite element analysis predicts CaScientific reports · 2021
    Article
  12. Sarcoplasmic reticular CaScientific reports · 2021
    Article
  13. Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Haseeb ValliPhysiological Laboratory, University of Cambridge, Cambridge, UK.
Shiraz AhmadPhysiological Laboratory, University of Cambridge, Cambridge, UK.
Sujan SriharanPhysiological Laboratory, University of Cambridge, Cambridge, UK.
Lydia D DeanPhysiological Laboratory, University of Cambridge, Cambridge, UK.
Andrew A GraceDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Kamalan JeevaratnamPhysiological Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6232-388X
Hugh R MatthewsPhysiological Laboratory, University of Cambridge, Cambridge, UK.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9553-6112
University of Cambridge · GB

Funding

British Heart Foundation PG/14/79/31102British Heart Foundation PG/15/12/31280Medical Research Council MR/M001288/1Wellcome TrustWellcome Trust 105727/Z/14/Z
6 · The paper itself

Abstract

Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly perturbs myocyte Ca

Indexed as

Action PotentialsAnimalsCalciumCyclic AMPDantroleneGene Expression RegulationGuanine Nucleotide Exchange FactorsHeartMiceMice, Inbred C57BLMicroelectrodesMuscle Relaxants, CentralMyocytes, CardiacPatch-Clamp TechniquesRyanodine Receptor Calcium Release ChannelSodium Channels8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphateCalciumCyclic AMPDantroleneEpac protein, mouseGuanine Nucleotide Exchange FactorsMuscle Relaxants, Centralryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelSodium Channels8-(4-chlorophenylthio)-2′-O-methyladenosine-3′,5′-cyclic monophosphatearrhythmic substrateCa2+ homeostasisconduction velocitydantroleneEpacNa+ currentryanodine receptor

Identifiers

PMID29027245
PMCPMC5814738
OpenAlexW2762467286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.