Evidence map›Paper›PMID 29027985›Full record

ArticleMolecules (Basel, Switzerland)2017

Triterpenoids from Ocimum labiatum Activates Latent HIV-1 Expression In Vitro: Potential for Use in Adjuvant Therapy.

Petrina Kapewangolo, Justin J Omolo, Pascaline Fonteh, Martha Kandawa-Schulz, Debra Meyer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. HIV cure strategies: which ones are appropriate for Africa?Cellular and molecular life sciences : CMLS · 2022
    Review
  2. Review
  3. Review
  4. Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Petrina KapewangoloDepartment of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Hatfield Campus, Pretoria 0002, South Africa. pkapewangolo@unam.na.
Justin J OmoloDepartment of Traditional Medicine, National Institute for Medical Research, P.O. Box 9653, Dar es Salaam 2448, Tanzania. jusiomolo@yahoo.com.
Pascaline FontehDepartment of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Hatfield Campus, Pretoria 0002, South Africa. pascaline.fru-fonteh@wits.ac.za.
Martha Kandawa-SchulzDepartment of Chemistry and Biochemistry, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek 9000, Namibia. kschulz@unam.na.
Debra MeyerDepartment of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Hatfield Campus, Pretoria 0002, South Africa. dmeyer@uj.ac.za.
University of Namibia · NANational Institute for Medical Research · TZUniversity of Johannesburg · ZAUniversity of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Latent HIV reservoirs in infected individuals prevent current treatment from eradicating infection. Treatment strategies against latency involve adjuvants for viral reactivation which exposes viral particles to antiretroviral drugs. In this study, the effect of novel triterpenoids isolated from

Indexed as

Gene Expression Regulation, ViralHistone DeacetylasesHIV-1HIV InfectionsHumansInterleukin-2Leukocytes, MononuclearOcimumTriterpenesTumor Necrosis Factor-alphaVirus ActivationHistone DeacetylasesInterleukin-2TriterpenesTumor Necrosis Factor-alphacytokineshistone deacetylaseHIV-1 eradicationlatent HIV-1novel triterpenoidsOcimum labiatumprotein kinase C

Identifiers

PMID29027985
PMCPMC6151608
OpenAlexW2764046667

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.