ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Negative Affect Is Associated With Higher Risk of Incident Cognitive Impairment in Nondepressed Postmenopausal Women.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Psychological characteristics and functional abilities in older adults with subjective cognitive complaints: A potential new target for early intervention.International psychogeriatrics · 2026Trial
- Amygdalar Pattern Similarity to Negative and Neutral Images, Ratings of the Images, and PET-Measured Amyloid and Tau Levels in Older Adults Without Dementia.Affective science · 2026Article
- The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective.Neuron · 2026Review
- Quality of life, religion/spirituality, and dementia risk among Black people in the US.Aging & mental health · 2025Observational
- Characterization of cancer survivors clustered by subjective and objective cognitive function scores.Cancer medicine · 2024Article
- Correlations between Dementia and Loneliness.International journal of molecular sciences · 2023Review
- Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice.CNS neuroscience & therapeutics · 2023Article
- Well-Being as a Protective Factor Against Cognitive Decline and Dementia: A Review of the Literature and Directions for Future Research.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Review
- Using Machine Learning to Predict Cognitive Impairment Among Middle-Aged and Older Chinese: A Longitudinal Study.International journal of public health · 2023Article
- Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline.Scientific reports · 2022Article
- The association between facets of conscientiousness and performance-based and informant-rated cognition, affect, and activities in older adults.Journal of personality · 2022Article
- Racial Differences in Associations of Cognitive Health Status With Happiness, Helplessness, and Hopelessness Among Older Adults: An Exploratory Study.Frontiers in aging neuroscience · 2022Article
- Loneliness and Risk of Dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Article
- The Mediating Effects of Affect on Associations between Impulsivity or Resilience and Internet Gaming Disorder.Journal of clinical medicine · 2019Article
- Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort.Journal of Alzheimer's disease : JAD · 2019Observational
- Psychological Distress, Self-Beliefs, and Risk of Cognitive Impairment and Dementia.Journal of Alzheimer's disease : JAD · 2018Article
- Association of Lower Spiritual Well-Being, Social Support, Self-Esteem, Subjective Well-Being, Optimism and Hope Scores With Mild Cognitive Impairment and Mild Dementia.Frontiers in psychology · 2018Article
- Evaluations of a Previous Day as a Pathway Between Personality and Healthy Cognitive Aging.Journal of aging and healthArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Background: Positive affect (PA) and negative affect (NA) reflect subjective emotional experiences. Although related to depression and anxiety, these dimensions are distinct constructs representing affective states and patterns. Prior studies suggest that elevated depressive symptoms are associated with risk of mild cognitive impairment (MCI) and probable dementia, but whether affective states are associated with cognitive impairment is still unknown. The present study examined relationships between baseline affective states and cognitive impairment (MCI, probable dementia) in nondepressed women. Method: Baseline PA and NA were assessed in postmenopausal women (N = 2,137; mean age = 73.8 years) from the Women's Health Initiative Study of Cognitive Aging (WHISCA) using the Positive and Negative Affect Schedule (PANAS). Women were followed annually for an average of 11.3 years; those with elevated depressive symptoms at baseline were excluded. Results: Higher NA was associated with a higher risk of MCI and probable dementia, even after adjusting for important covariates including age, education, sociodemographic, lifestyle, and cardiovascular risk factors, global cognition, and hormone therapy assignment at baseline. PA was not significantly associated with either outcome. Conclusions: We present the first evidence to date that greater NA, even in the absence of elevated depressive symptoms, is associated with higher risk of MCI and dementia. This suggests that NA may be an important, measureable and potentially modifiable risk factor for age-related cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.