Evidence map›Paper›PMID 29033587›Full record

ArticleOncoTargets and therapy2017

DNA hypermethylated status and gene expression of

Jin Huang, Zhi-Rong Tan, Jing Yu, He Li, Qiao-Li Lv, Ying-Ying Shao, Hong-Hao Zhou

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. A Novel Prognostic DNA Methylation Panel for Colorectal Cancer.International journal of molecular sciences · 2019
    Trial
  2. Review
  3. Article
  4. PAX Family, Master Regulator in Cancer.Diagnostics (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Methylation ofJournal of Cancer · 2021
    Article
  12. Frontiers in genetics · 2020
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jin HuangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan.
Zhi-Rong TanDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan.
Jing YuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan.
He LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan.
Qiao-Li LvDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan.
Ying-Ying ShaoInstitute of Life Science, Chongqing Medical University, Yuzhong District, Chongqing, China.
Hong-Hao ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan.
Central South University · CNPharmacoGenetics (China) · CNXiangya Hospital Central South University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a widespread and aggressive carcinoma with poor prognosis. Hypermethylation of specific gene promoters is an important mechanism of CRC. In this study, we investigated the hypermethylation of paired boxed gene 1 (

methodsDNA methylation at cg2,09,07,471

resultsMethylation levels of

conclusionsThis study is the first analysis of the methylation of

Indexed as

colorectal cancerDNA methylationepigeneticmolecular biomarkerPAX1SOX1

Identifiers

PMID29033587
PMCPMC5628670
OpenAlexW2758170428

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.