ArticlePloS one2017
Predictors of adverse drug reaction-related hospitalisation in Southwest Ethiopia: A prospective cross-sectional study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The association between age and medication-related hospital admission in adults: a systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Variation of adverse drug events in different settings in Africa: a systematic review.European journal of medical research · 2024Pooled it
- Serious adverse drug reactions in sub-Saharan Africa in the era of antiretroviral treatment: A systematic review.Pharmacology research & perspectives · 2021Pooled it
- Medication-related problems and adverse drug reactions in Ethiopia: A systematic review.Pharmacology research & perspectives · 2020Pooled it
- Machine Learning Algorithms for Adverse Drug Reactions Prediction and Identifying Its Determinants Among HIV Patients on Antiretroviral Therapy in the University of Gondar Comprehensive and Specialized Hospital, in Amhara Region, Ethiopia.Health science reports · 2025Article
- Joint modeling of predictors of adverse drug reactions and viral load changes over time among adult patients on ART at Nigist Eleni Mohammed Memorial comprehensive specialized hospital, central Ethiopia.BMC infectious diseases · 2025Article
- Observational
- Article
- Predictors of Adverse Drug Reaction-Related Hospitalisations Among People with Dementia: A Retrospective Case-Control Study.Drug safety · 2024Article
- Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method.Frontiers in pharmacology · 2024Article
- A Systematic Review of Healthcare Professionals' Knowledge, Attitudes, and Practices Regarding Adverse Drug Reaction Reporting in Ethiopia.Turkish journal of pharmaceutical sciences · 2023Article
- Under-reporting of adverse drug reactions: Surveillance system evaluation in Ho Municipality of the Volta Region, Ghana.PloS one · 2023Article
- Risk factors for and characteristics of community- and hospital-acquired drug-induced acute kidney injuries.Fundamental & clinical pharmacology · 2022Article
- Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study.BMC pharmacology & toxicology · 2022Observational
- Predictors of hospital-acquired adverse drug reactions: a cohort of Ugandan older adults.BMC geriatrics · 2022Article
- Drug-Related Hospital Admissions and Associated Factors among Adults Admitted to Felege Hiwot Comprehensive and Specialized Hospital, North West Ethiopia.Journal of environmental and public health · 2022Article
- ADR in Journals: Are They Translated into Regulatory Frameworks?Current drug safety · 2022Article
- Drug-Related Hospital AdmissionsFrontiers in pharmacology · 2022Article
- Knowledge, Attitude, and Practice of Medical, Pharmacy, and Nursing Students Towards Pharmacovigilance and Adverse Drug Reaction Reporting at University of Gondar College of Medicine and Health Sciences, Northwest Ethiopia: A Cross-Sectional Study.Advances in medical education and practice · 2021Article
- Prevalence, Incidence, and Characteristics of Adverse Drug Reactions Among Older Adults Hospitalized at Mbarara Regional Referral Hospital, Uganda: A Prospective Cohort Study.Clinical interventions in aging · 2021Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
backgroundAdverse drug reactions (ADRs) are important causes of morbidity and mortality in the healthcare system; however, there are no studies reporting on the magnitude and risk factors associated with ADR-related hospitalisation in Ethiopia.
objectivesTo characterise the reaction types and the drugs implicated in admission to Jimma University Specialized Hospital, Southwest Ethiopia, and to identify risk factors associated with ADR-related hospitalisation.
methodsA prospective cross-sectional study was conducted from May 2015 to August 2016 among consenting patients aged ≥18 years consecutively admitted to medical wards taking at least one medication prior to admission. ADR-related hospitalisations were determined through expert review of medical records, laboratory tests, patient interviews and physical observation. ADR causality was assessed by the Naranjo algorithm followed by consensus review with internal medicine specialist. ADR preventability was assessed using Schumock and Thornton's criteria. Only definite and probable ADRs that provoked hospitalisation were considered. Binary logistic regression was used to identify independent predictors of ADR-related hospitalisation.
resultsOf 1,001 patients, 103 (10.3%) had ADR-related admissions. Common ADRs responsible for hospitalisation were hepatotoxicity (35, 29.4%) and acute kidney injury (27, 22.7%). The drug classes most frequently implicated were antitubercular agents (45, 25.0%) followed by antivirals (22, 12.2%) and diuretics (19, 10.6%). Independent predictors of ADR-related hospitalisation were body mass index (BMI) <18.5 kg/m2 (adjusted odd ratio [AOR] = 1.69; 95% confidence interval [CI] = 1.10-2.62; p = 0.047), pre-existing renal disease (AOR = 2.84; 95%CI = 1.38-5.85, p = 0.004), pre-existing liver disease (AOR = 2.61; 95%CI = 1.38-4.96; p = 0.003), number of comorbidities ≥4 (AOR = 2.09; 95%CI = 1.27-3.44; p = 0.004), number of drugs ≥6 (AOR = 2.02; 95%CI = 1.26-3.25; p = 0.004) and history of previous ADRs (AOR = 24.27; 95%CI = 11.29-52.17; p<0.001). Most ADRs (106, 89.1%) were preventable.
conclusionsADRs were a common cause of hospitalisation. The majority of ADRs were preventable, highlighting the need for monitoring and review of patients with lower BMI, ADR history, renal and liver diseases, multiple comorbidities and medications. ADR predictors should be integrated into clinical pathways and pharmacovigilance systems.
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