SynthesisPloS one2017
Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 358 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Management of Intrapartum Glycemia in Gestational Diabetic Mothers: A Randomized Controlled Trial
Fetal, Obstetrics and Reproduction Genomics
Who cites it
358 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Prevalence and risk factors associated with birth asphyxia among neonates delivered in China: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials.Biomolecules & biomedicine · 2024Pooled it
- The Population-Attributable Fractions of Small-for-Gestational-Age Births: Results from the Japan Birth Cohort Consortium.Nutrients · 2024Pooled it
- Does paternal age affect the live birth rate in donor oocyte cycles? A systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2023Pooled it
- The Effect of Local Infiltration of Dexmedetomidine as an Adjuvant on Breakthrough Pain During Epidural Labor Analgesia: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Trial
- Prenatal exposure to DEHTP replacement metabolites and odds of preeclampsia and gestational hypertension in a diverse nulliparous U.S. cohort.Environmental advances · 2026Article
- Maternal and perinatal outcomes across China's one-child, two-child, and three-child policy periods: a retrospective cohort analysis of 43,439 deliveries.Journal of global health · 2026Article
- Development and validation of a predictive nomogram for cesarean delivery in term singleton pregnancies complicated by small for gestational age undergoing labor induction.Scientific reports · 2026Article
- Magnesium and Diabetes: A Review of Recent Studies on the Efficacy of Supplementation with Mg in Humans Suffering from This Chronic Metabolic Disease.International journal of molecular sciences · 2026Review
- Sleep Disorders and the Influence of Maternal Age in Young Children With Autism Spectrum Disorder: A Retrospective Cross-sectional Study.Journal of autism and developmental disorders · 2026Article
- Pathological semen parameters according to WHO and Austrian IVF funds criteria and their association with pregnancy outcomes in assisted reproduction.Wiener medizinische Wochenschrift (1946) · 2026Article
- Pregnancy Outcome in Women Aged 40 Years and Above: A Cross Sectional Study.Journal of obstetrics and gynaecology of India · 2026Article
- Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium.iMeta · 2026Article
- Association between gestational weight gain and adverse pregnancy outcomes in advanced maternal age: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Article
- Fetal and Obstetric Complications Among Pregnant Women With Congenital Heart Disease in a Georgia Medicaid Dataset.Birth defects research · 2026Article
- Review
- Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.Aging cell · 2026Article
298 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications.
objectiveTo determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA. SEARCH STRATEGY: Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000. SELECTION CRITERIA: Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and <35 years. DATA COLLECTION AND ANALYSIS: The effect of age on pregnancy outcome was investigated by random effects meta-analysis and meta-regression. Stillbirth rates were correlated to rates of maternal diabetes, obesity, hypertension and use of assisted reproductive therapies (ART). MAIN
resultsOut of 1940 identified titles; 63 cohort studies and 12 case-control studies were included in the meta-analysis. AMA increased the risk of stillbirth (OR 1.75, 95%CI 1.62 to 1.89) with a population attributable risk of 4.7%. Similar trends were seen for risks of FGR, neonatal death, NICU unit admission restriction and GDM. The relationship between AMA and stillbirth was not related to maternal morbidity or ART.
conclusionsStillbirth risk increases with increasing maternal age. This is not wholly explained by maternal co-morbidities and use of ART. We propose that placental dysfunction may mediate adverse pregnancy outcome in AMA. Further prospective studies are needed to directly test this hypothesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.