ArticleJournal of clinical lipidology
Association of low-density lipoprotein pattern with mortality after myocardial infarction: Insights from the TRIUMPH study.
Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association between basal metabolic rate and cardio-metabolic risk factors: Evidence from a Mendelian Randomization study.Heliyon · 2024Article
- Alterations of NMR-Based Lipoprotein Profile Distinguish Unstable Angina Patients with Different Severity of Coronary Lesions.Metabolites · 2023Article
- Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health.Molecules (Basel, Switzerland) · 2022Article
- [The ketogenic diet: history, mechanism of action, indications and contraindications].Problemy endokrinologii · 2021Article
- Risk Assessment and Clinical Management of Children and Adolescents with Heterozygous Familial Hypercholesterolaemia. A Position Paper of the Associations of Preventive Pediatrics of Serbia, Mighty Medic and International Lipid Expert Panel.Journal of clinical medicine · 2021Review
- Correlation between small and dense low-density lipoprotein cholesterol and cardiovascular events in Beijing community population.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Low-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.Frontiers in neurology · 2021Article
- Prevalence, treatment, and control of severe hyperlipidemia.American journal of preventive cardiology · 2020Article
- The Lipid Paradox is present in ST-elevation but not in non-ST-elevation myocardial infarction patients: Insights from the Singapore Myocardial Infarction Registry.Scientific reports · 2020Observational
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundStudies of incident coronary heart disease risk within low-density lipoprotein (LDL) subclass (small, dense vs large, buoyant) have shown mixed results. No prospective cohort study has examined the association of small, dense, or large, buoyant LDL with mortality after myocardial infarction (MI).
objectiveThe objective of the study was to examine association of LDL pattern after MI and death.
methodsIn 2476 patients hospitalized for MI, LDL pattern (A [large, buoyant], A/B [mixed], and B [small, dense]) was established by ultracentrifugation using Vertical Auto Profile. Using time-to-event analysis, we examined the association with 5-year mortality within LDL patterns, after adjusting for important patient and treatment characteristics. We additionally adjusted for LDL cholesterol (LDL-C) and triglyceride levels and used directly measured LDL-C and non-high-density lipoprotein cholesterol as exposures.
resultsPatterns A, A/B, and B were present in 39%, 28%, and 33% of patients, respectively, with incident rates (per 1000 patient-years) of 50, 34, and 24 for all-cause and 24, 19, and 10 for CV mortality. The hazard ratios (95% confidence interval) with LDL patterns A/B and B compared with pattern A were 0.77 (0.61, 0.99) and 0.67 (0.51, 0.88) for all-cause, 0.94 (0.67, 1.33) and 0.69 (0.46, 1.03) for cardiovascular, and 0.64 (0.45, 0.91) and 0.65 (0.45, 0.93) for noncardiovascular mortalities, respectively. Results were similar when further adjusted for LDL-C and triglycerides, or with LDL-C and non-high-density lipoprotein cholesterol as exposures.
conclusionCompared with LDL pattern A, pattern B was significantly associated with reduced all-cause and non-CV mortalities with a trend for lower CV mortality after MI, independent of LDL-C and triglycerides.
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