Evidence map›Paper›PMID 29059010›Full record

ReviewAnnual review of pathology2018

Stem Cell Pathology.

Dah-Jiun Fu, Andrew D Miller, Teresa L Southard, Andrea Flesken-Nikitin, Lora H Ellenson, Alexander Yu Nikitin

Abstract readReview
In one paragraph

Review in Annual review of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dah-Jiun FuDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA; email: an58@cornell.edu.
Andrew D MillerDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA; email: an58@cornell.edu.
Teresa L SouthardDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA; email: an58@cornell.edu.
Andrea Flesken-NikitinDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA; email: an58@cornell.edu.
Lora H EllensonDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Alexander Yu NikitinDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA; email: an58@cornell.edu.

Funding

Reproductive Sciences and Genomics Training ProgramT32HD052471 · NICHD · CORNELL UNIVERSITY · PI ROBERSON, MARK S · 2007 to 2016
$2.0M
Origins of Ovarian CarcinomaR01CA182413 · NCI · CORNELL UNIVERSITY · PI NIKITIN, ALEXANDER Y. · 2015 to 2019
$1.8M
Neuroendocrine mechanisms of prostate cancer progressionR01CA197160 · NCI · CORNELL UNIVERSITY · PI NIKITIN, ALEXANDER Y. · 2015 to 2020
$1.8M
NCI NIH HHS R01 CA182413NCI NIH HHS R01 CA197160NICHD NIH HHS T32 HD052471
6 · The paper itself

Abstract

Rapid advances in stem cell biology and regenerative medicine have opened new opportunities for better understanding disease pathogenesis and the development of new diagnostic, prognostic, and treatment approaches. Many stem cell niches are well defined anatomically, thereby allowing their routine pathological evaluation during disease initiation and progression. Evaluation of the consequences of genetic manipulations in stem cells and investigation of the roles of stem cells in regenerative medicine and pathogenesis of various diseases such as cancer require significant expertise in pathology for accurate interpretation of novel findings. Therefore, there is an urgent need for developing stem cell pathology as a discipline to facilitate stem cell research and regenerative medicine. This review provides examples of anatomically defined niches suitable for evaluation by diagnostic pathologists, describes neoplastic lesions associated with them, and discusses further directions of stem cell pathology.

Indexed as

Regenerative MedicineStem Cell NicheHumansNeoplasmsStem Cellscancerdisease pathogenesismouse modelsstem cell biologystem cell nichestissue evaluation

Identifiers

PMID29059010
PMCPMC5857951

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.