ArticleScientific reports2017
Live Cell Imaging Reveals pH Oscillations in Saccharomyces cerevisiae During Metabolic Transitions.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Regulatory dynamics of Sch9 in response to cytosolic acidification: From spatial reconfiguration to cellular adaptation to stresses.iScience · 2025Article
- Signaling events that occur when cells ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Synchronisation of glycolytic activity in yeast cells.Current genetics · 2022Review
- Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning.Nature communications · 2022Article
- Methanogenic archaea use a bacteria-like methyltransferase system to demethoxylate aromatic compounds.The ISME journal · 2021Article
- Article
- Proper regulation of inositolphosphorylceramide levels is required for acquirement of low pH resistance in budding yeast.Scientific reports · 2020Article
- In vivo characterisation of fluorescent proteins in budding yeast.Scientific reports · 2019Article
- Flavin-based metabolic cycles are integral features of growth and division in single yeast cells.Scientific reports · 2018Article
- Is a constant low-entropy process at the root of glycolytic oscillations?Journal of biological physics · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Addition of glucose to starved Saccharomyces cerevisiae initiates collective NADH dynamics termed glycolytic oscillations. Numerous questions remain about the extent to which single cells can oscillate, if oscillations occur in natural conditions, and potential physiological consequences of oscillations. In this paper, we report sustained glycolytic oscillations in single cells without the need for cyanide. Glucose addition to immobilized cells induced pH oscillations that could be imaged with fluorescent sensors. A population of cells had oscillations that were heterogeneous in frequency, start time, stop time, duration and amplitude. These changes in cytoplasmic pH were necessary and sufficient to drive changes in NADH. Oscillators had lower mitochondrial membrane potentials and budded more slowly than non-oscillators. We also uncovered a new type of oscillation during recovery from H
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Registered trials
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