ArticleAlzheimer's & dementia (New York, N. Y.)2016
Poor cerebrovascular function is an early marker of cognitive decline in healthy postmenopausal women.
Article in Alzheimer's & dementia (New York, N. Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults.Nutrients · 2018Trial
- Trial
- Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults.Aging and disease · 2024Review
- Normative Cerebral Hemodynamics in Middle-aged and Older Adults Using 4D Flow MRI: Initial Analysis of Vascular Aging.Radiology · 2023Article
- β-Estradiol 17-acetate enhances theNeural regeneration research · 2023Article
- Exploration of cerebral hemodynamic pathways through which large artery function affects neurovascular coupling in young women.Frontiers in cardiovascular medicine · 2022Article
- Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women.Nutrients · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
introductionImpairment of cerebrovascular function becomes evident after menopause. No study has yet explored relationships between deficits in cerebrovascular function, cognitive performance, and mood in postmenopausal women.
methodCerebrovascular function was assessed in 80 healthy postmenopausal women by monitoring blood flow velocity (BFV) in the middle and posterior cerebral arteries using transcranial Doppler ultrasound at rest, following a hypercapnic challenge, and during performance of a cognitive test battery; the latter assessed domains of memory and executive functions. Various measures of mood (i.e., Profile of Mood States and Center for Epidemiological Studies Depression Scale) were also assessed.
resultsCerebral artery elasticity and BFV responsiveness to cognitive tests (neurovascular coupling) correlated with cognitive performance but not with depressive symptoms or mood states. Mood deficits were related to poor cognitive performance.
conclusionThese results highlight the importance of adequate cerebral perfusion for optimized cognitive function in healthy postmenopausal women. Preventative strategies to attenuate accelerated cognitive decline should also consider restoring cerebrovascular function.
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