Evidence map›Paper›PMID 29072800›Full record

Trial reportDiabetes, obesity & metabolism2018

Effect of sitagliptin on glucose control in type 2 diabetes mellitus after Roux-en-Y gastric bypass surgery.

Ankit Shah, Kiarra Levesque, Esmeralda Pierini, Betsy Rojas, Michael Ahlers, Sarah Stano, Marlena Holter, Roxanne Dutia, Scott Belsley, James McGinty and 1 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Long-Term Weight Loss Strategies for Obesity.The Journal of clinical endocrinology and metabolism · 2021
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ankit ShahDivision of Endocrinology, Department of Medicine, Columbia University Medical Center, New York, New York.
Kiarra LevesqueNew York Obesity Research Center, Columbia University, New York, New York.
Esmeralda PieriniNew York Obesity Research Center, Columbia University, New York, New York.
Betsy RojasBariatric Division, Department of Surgery, Mount Sinai St. Luke's, New York, New York.
Michael AhlersNew York Obesity Research Center, Columbia University, New York, New York.
Sarah StanoNew York Obesity Research Center, Columbia University, New York, New York.
Marlena HolterNew York Obesity Research Center, Columbia University, New York, New York.
Roxanne DutiaNew York Obesity Research Center, Columbia University, New York, New York.
Scott BelsleyBariatric Division, Department of Surgery, Mount Sinai St. Luke's, New York, New York.
James McGintyBariatric Division, Department of Surgery, Mount Sinai St. Luke's, New York, New York.
Blandine LaferrèreDivision of Endocrinology, Department of Medicine, Columbia University Medical Center, New York, New York.ORCID 0000-0001-8255-3175
Columbia University · USMount Sinai Hospital · USColumbia University Irving Medical Center · US

Funding

Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Remi J Creusot · 2003 to 2026
$36.7M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
TRAINING PROGRAM IN ENDOCRINOLOGY AND METABOLISMT32DK007271 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ACCILI, DOMENICO · 1986 to 2019
$6.1M
OBESITY RESEARCH CENTER TRAINING PROGRAMT32DK007559 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI DYMPNA GALLAGHER · 1989 to 2026
$4.3M
Mechanisms of Diabetes Control After Weight Loss SurgeryR01DK067561 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 2005 to 2013
$3.1M
Long term change of GLP-1 insulinotropic effect after GBP surgeryR01DK098056 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAFERRERE, BLANDINE B · 2014 to 2017
$1.9M
NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK063608NIDDK NIH HHS R01 DK067561NIDDK NIH HHS R01 DK098056NIDDK NIH HHS T32 DK007271NIDDK NIH HHS T32 DK007559
6 · The paper itself

Abstract

The present study was a 4-week randomized trial to assess the efficacy and safety of sitagliptin, a dipeptidyl-peptidase-4 inhibitor, in persistent or recurring type 2 diabetes after Roux-en-Y gastric bypass surgery (RYGB). Participants (n = 32) completed a mixed meal test (MMT) and self-monitoring of plasma glucose (SMPG) before and 4 weeks after randomization to either sitagliptin 100 mg daily or placebo daily. Questionnaires were administered to assess gastrointestinal discomfort. Outcome variables were glucose, active glucagon-like peptide-1 and β-cell function during the MMT, and glucose levels during SMPG. Age (56.3 ± 8.2 years), body mass index (34.4 ± 6.7 kg/m

Indexed as

Gastric BypassAdultAgedBlood GlucoseCombined Modality TherapyDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansLongitudinal StudiesMaleMiddle AgedSitagliptin PhosphateBlood GlucoseGlycated HemoglobinSitagliptin Phosphatedipeptidyl-peptidase 4 inhibitorgastric bypasstype 2 diabetes

Identifiers

PMID29072800
PMCPMC5847464
OpenAlexW2766110521

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.