Evidence map›Paper›PMID 29073364›Full record

ReviewAnnals of the American Thoracic Society2017

Genetic, Immunologic, and Environmental Basis of Sarcoidosis.

David R Moller, Ben A Rybicki, Nabeel Y Hamzeh, Courtney G Montgomery, Edward S Chen, Wonder Drake, Andrew P Fontenot

Abstract readReview
In one paragraph

Review in Annals of the American Thoracic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Sarcoidosis as an Autoimmune Disease.Frontiers in immunology · 2019
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Cardiovascular Manifestations and Immunobiology of Sarcoidosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. The Role ofInternational journal of molecular sciences · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Autoantibodies in sarcoidosis: Innocent bystander or promising biomarker for organ involvement?Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David R Moller1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland.
Ben A Rybicki2 Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.
Nabeel Y Hamzeh3 National Jewish Health, Denver, Colorado.
Courtney G Montgomery4 Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Edward S Chen1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland.
Wonder Drake5 Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Andrew P Fontenot6 Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.

Funding

Comprehensive Genome Interrogation of African American Sarcoidosis FamiliesR01HL113326 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MONTGOMERY, COURTNEY · 2012 to 2022
$8.7M
T cell epitopes in sarcoidosisR01HL136137 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PALMER, BRENT E · 2017 to 2024
$4.7M
Genetic Risk for Granulomatous Interstitial Lung DiseaseR01HL114587 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E. · 2013 to 2018
$3.2M
Mentoring in Translational Research in Interstitial Lung DiseasesK24HL127301 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wonder P. Drake · 2016 to 2026
$1.2M
GRADS Cooperative Research Project: JHU Clinical CenterU01HL112708 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MOLLER, DAVID R · 2012 to 2014
$481k
Immunologic and Molecular Phenotypes in AATD and SarcoidosisU01HL112695 · NHLBI · NATIONAL JEWISH HEALTH · PI MAIER, LISA A · 2012 to 2014
$465k
Investigation of microbial hetergeneity to sarcoidosis and AAT clinical outcomeU01HL112694 · NHLBI · VANDERBILT UNIVERSITY · PI DRAKE, WONDER P. · 2012 to 2014
$463k
NHLBI NIH HHS K24 HL127301NHLBI NIH HHS R01 HL113326NHLBI NIH HHS R01 HL114587NHLBI NIH HHS R01 HL136137NHLBI NIH HHS U01 HL112694NHLBI NIH HHS U01 HL112695NHLBI NIH HHS U01 HL112708
6 · The paper itself

Abstract

Sarcoidosis is a multisystem disease with tremendous heterogeneity in disease manifestations, severity, and clinical course that varies among different ethnic and racial groups. To better understand this disease and to improve the outcomes of patients, a National Heart, Lung, and Blood Institute workshop was convened to assess the current state of knowledge, gaps, and research needs across the clinical, genetic, environmental, and immunologic arenas. We also explored to what extent the interplay of the genetic, environmental, and immunologic factors could explain the different phenotypes and outcomes of patients with sarcoidosis, including the chronic phenotypes that have the greatest healthcare burden. The potential use of current genetic, epigenetic, and immunologic tools along with study approaches that integrate environmental exposures and precise clinical phenotyping were also explored. Finally, we made expert panel-based consensus recommendations for research approaches and priorities to improve our understanding of the effect of these factors on the health outcomes in sarcoidosis.

Indexed as

Biomedical ResearchConsensusEnvironmental ExposureHumansNational Heart, Lung, and Blood Institute (U.S.)PhenotypeRisk FactorsSarcoidosisUnited Statesenvironmentgeneticsgranulomaimmunologyphenotype

Identifiers

PMID29073364
PMCPMC5822412

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.