Evidence map›Paper›PMID 29074304›Full record

ArticleNeuropharmacology2018

Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.

Megan L Brady, Jyotsna Pilli, Joshua M Lorenz-Guertin, Sabyasachi Das, Charles E Moon, Nicholas Graff, Tija C Jacob

Open access · bronzeAbstract read
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Function of the GABAergic System in Diabetic Encephalopathy.Cellular and molecular neurobiology · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Regulation of GABAMembranes · 2021
    Review
  19. Physiological role for GABANature communications · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Megan L BradyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Jyotsna PilliDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Joshua M Lorenz-GuertinDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Sabyasachi DasDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Charles E MoonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Nicholas GraffDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Tija C JacobDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: tcj11@pitt.edu.
University of Pittsburgh · US

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4M
NIGMS NIH HHS T32 GM008424NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

γ-aminobutyric acid (GABA) begins as the key excitatory neurotransmitter in newly forming circuits, with chloride efflux from GABA type A receptors (GABA

Indexed as

AnimalsAzepinesBenzamidesBrain-Derived Neurotrophic FactorButadienesCalcium Channel BlockersCerebral CortexEmbryo, MammalianEnzyme InhibitorsExcitatory Amino Acid AgentsExtracellular Signal-Regulated MAP KinasesGABA AgentsGlutamate DecarboxylaseGlutamic AcidMuscimolNeuronal PlasticityANA 12 compoundAzepinesBenzamidesBrain-Derived Neurotrophic FactorButadienesCalcium Channel BlockersEnzyme InhibitorsExcitatory Amino Acid AgentsExtracellular Signal-Regulated MAP KinasesGABA AgentsGlutamate Decarboxylaseglutamate decarboxylase 1Glutamic AcidMuscimolNimodipineNitrilesReceptors, GABA-AU 0126BDNFCalciumERKGABA type A receptorsInhibitionMuscimolNeuronal developmentSynaptic plasticity

Identifiers

PMID29074304
PMCPMC5739058
OpenAlexW2767141727

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.