ArticleThe Lancet. Child & adolescent health2017
Prediabetes in youth - mechanisms and biomarkers.
Article in The Lancet. Child & adolescent health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Global prevalence of prediabetes in children and adolescents: A systematic review and meta-analysis.Journal of diabetes · 2022Pooled it
- Pathophysiology of Type 2 Diabetes in Children and Adolescents.Current diabetes reviews · 2020Pooled it
- Associations between activity patterns and cardio-metabolic risk factors in children and adolescents: A systematic review.PloS one · 2018Pooled it
- Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial.Frontiers in endocrinology · 2023Trial
- Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1-Mediated Mechanism.The Journal of clinical endocrinology and metabolism · 2019Trial
- Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity.Pediatric diabetes · 2019Trial
- Mid-upper arm circumference and diabetes/prediabetes in children and adolescents: A cross-sectional study using NHANES data.Medicine · 2026Article
- Prediabetes in Indian Adolescents: A Window for Intervention.Indian journal of pediatrics · 2026Article
- 20/ (fasting C-peptide × fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents.Pediatric research · 2026Article
- Prediabetes in children and adolescents in Israel: a large-scale retrospective cohort study.European journal of pediatrics · 2026Article
- Prevalence of hyperinsulinemia and its association with measures of adiposity and body composition in 16-25-year-old adolescents and young adults in Mumbai.BMC endocrine disorders · 2026Article
- Early detection and risk stratification of insulin resistance in children and adolescents with excess weight: a sdLDL/oxLDL-Based model.Clinical and experimental medicine · 2026Article
- The prevalence of prediabetes is high and has rapidly increased, independent of the degree of obesity, in Finnish children with overweight or obesity.International journal of obesity (2005) · 2026Article
- Adipose tissue insulin resistance in children and adolescents: linking glucose and free fatty acid metabolism to hepatic injury markers.American journal of physiology. Endocrinology and metabolism · 2024Article
- Reversibility of Hyperglycemic States in Children with Obesity - Diagnostic Pitfalls in the Assessment of Glucose Metabolism in Children and Adolescents with ObesityJournal of clinical research in pediatric endocrinology · 2024Article
- Prevalence and outcome of chronic hypertension and its complications with gestational diabetes.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Prediabetes in children and adolescents: An updated review.World journal of clinical pediatrics · 2023Review
- Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity.JCI insight · 2023Article
- Effects of COVID-19 time on the development of pre-impaired glucose tolerance state in children and adolescents with overweight and obesity.International journal of obesity (2005) · 2023Article
- Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Obesity has been estimated to decrease life expectancy by as little as 0.8 to as much as 7 years being the second leading cause of preventable death in the United States after smoking. Along with the increase in the prevalence of obesity, there has been a dramatic rise of the prevalence of prediabetes and type 2 diabetes among adolescents. Despite that, very little is known about the pathogenesis of these conditions in pediatrics and about how we could detect prediabetes in an early stage in order to prevent full blown diabetes. In this review we summarize the current knowledge on the pathophysiology of prediabetes and type 2 diabetes in adolescents and describe how biomarkers of beta-cell function might help identifying those individuals who are prone to progress from normal glucose tolerance towards prediabetes and overt type 2 diabetes. To better understand and fight this disease, we will need to explore and develop novel therapeutic strategies and individuate more sensitive and specific biomarkers that can allow an earlier detection of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.