DPP-4 inhibitors × blood pressure

SynthesisBMJ open2017

Effectiveness of sitagliptin compared to sulfonylureas for type 2 diabetes mellitus inadequately controlled on metformin: a systematic review and meta-analysis.

Manuj Sharma et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2017

Range includes no effect

No clear effect on blood pressure

−2%−15% to +13%

Smaller than almost all on the map

As reported

OR 0.98, 95% CI 0.85–1.13

Not counted

Probably lowered glycemic control

−35%−43% to −27%

Bigger than 3 in 10 for glycemic control

As reported

HR 0.65, 95% CI 0.57–0.73

Not counted

Probably lowered glycemic control

−24%−35% to −10%

Bigger than 2 in 10 for glycemic control

As reported

HR 0.76, 95% CI 0.65–0.90

Three numbers in the abstract

the abstract, start to end

achieving HbA1c <7% by study end (OR 0.98; 95% CI 0.85 to 1.13) was

suggested that treatment change (HR 0.65; 95% CI 0.57 to 0.73) and insulin initiation (HR 0.76; 95% CI 0.65 to 0.90) were less

← favours treatmentfavours comparator →
could be chance
Blood pressure
OR 0.980.85–1.13
Glycemic control
HR 0.650.57–0.73
Glycemic control
HR 0.760.65–0.90
DPP-4 inhibitorsSulfonylureas & glinidesInsulinGlycemic controlBlood pressure

Sulfonylureas & glinides × blood pressurehelps?mixed

unlikelylikely
0.00not counted
← favours comparatorfavours treatment →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 29084794