ReviewJournal of comorbidity2011
Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium.
Review in Journal of comorbidity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 303 citations in OpenAlex.
- A Systematic Review of the Patterns of Associative Multimorbidity in Asia.BioMed research international · 2021Pooled it
- Multifaceted self-management interventions for older women with urinary incontinence: a systematic review and narrative synthesis.BMJ open · 2019Pooled it
- Impact of pharmacist interventions on drug-related problems in general surgery patients: a randomised controlled trial.European journal of hospital pharmacy : science and practice · 2021Trial
- Safety profile of gadoxetate disodium in elderly patients (≥65 years).Acta radiologica (Stockholm, Sweden : 1987) · 2018Trial
- Low-Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle-Aged and Older Adults: Study Protocol for a Triple-Blind, Randomised, Placebo-Controlled Trial.Basic & clinical pharmacology & toxicology · 2026Article
- Associations of Polypharmacy, Diuretics and Antipsychotics with Injurious Falls: A Population-Based Cohort Study.Drugs & aging · 2026Article
- Medication Adherence in Comorbid Hypertension and Diabetes: An Exploratory Descriptive Qualitative Study of Healthcare Providers' Perspectives.Health science reports · 2026Article
- Metoprolol Population Pharmacokinetics in Older Chinese Patients With CKM Syndrome: Joint Effects of rs1065852 and CKMClinical and translational science · 2026Article
- Non-Pharmacological Treatments of Migraine: Current Evidence and Clinical Practice.Current pain and headache reports · 2026Review
- Article
- Metformin Partially Attenuates Simvastatin-Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Prevalence and Associated Factors of Polypharmacy Among Emirati Community-Dwelling Older Adults: A Cross-Sectional Survey.Healthcare (Basel, Switzerland) · 2026Article
- Patient Activation Among Individuals with Chronic Illness: A Cross-Sectional Study from Jordan.Healthcare (Basel, Switzerland) · 2026Article
- Prescription Trends of Initial Antihypertensive Medications Among Presumed Treatment-Naïve Individuals in Korea: A Retrospective Analysis.Journal of Korean medical science · 2026Article
- A novel prognostic nomogram for elderly renal cell carcinoma patients with lung metastases.Scientific reports · 2026Article
- Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations.Pharmaceutics · 2025Review
- The Cognitive and Mood-Related Costs of Loneliness: Why Marital Status Matters in Old Age.Geriatrics (Basel, Switzerland) · 2025Article
- Prescribing Patterns of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Patients With T2DM and ASCVD in South Korea.Pharmacoepidemiology and drug safety · 2025Article
- Performance of Machine Learning Models in Predicting 30-Day General Medicine Readmissions Compared to Traditional Approaches in Australian Hospital Setting.Healthcare (Basel, Switzerland) · 2025Article
- The impact of age on the survival outcomes of hepatocellular carcinoma patients after transarterial chemoembolization: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern of patients admitted to internal medicine wards has dramatically changed in the last 20-30 years. Elderly people are now the most rapidly growing proportion of the patient population in the majority of Western countries, and aging seldom comes alone, often being accompanied by chronic diseases, comorbidity, disability, frailty, and social isolation. Multiple diseases and multimorbidity inevitably lead to the use of multiple drugs, a condition known as polypharmacy. Over the last 20-30 years, problems related to aging, multimorbidity, and polypharmacy have become a prominent issue in global healthcare. This review discusses how internists might tackle these new challenges of the aging population. They are called to play a primary role in promoting a new, integrated, and comprehensive approach to the care of elderly people, which should incorporate age-related issues into routine clinical practice and decisions. The development of new approaches in the frame of undergraduate and postgraduate training and of clinical research is essential to improve and implement suitable strategies meant to evaluate and manage frail elderly patients with chronic diseases, comorbidity, and polypharmacy. Journal of Comorbidity 2011;1:28-44.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.