Evidence map›Paper›PMID 29101179›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca

Bojun Zhang, Jay S Naik, Nikki L Jernigan, Benjimen R Walker, Thomas C Resta

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Store-operated CaAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  2. Article
  3. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  4. Article
  5. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. When higher cholesterol is better: membrane cholesterol loss and endothelial CaAmerican journal of physiology. Heart and circulatory physiology · 2018
    Article
  15. Cortical Actin Dynamics in Endothelial Permeability.Current topics in membranes · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bojun ZhangVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Jay S NaikVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.ORCID 0000-0002-5725-4664
Nikki L JerniganVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Benjimen R WalkerVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
Thomas C RestaVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center , Albuquerque, New Mexico.
University of New Mexico · US

Funding

PULMONARY ENDOTHELIAL FUNCTION DURING CHRONIC HYPOXIAR01HL058124 · NHLBI · UNIVERSITY OF NEW MEXICO · PI WALKER, BENJIMEN R · 1999 to 2008
$2.1M
Pulmonary Vasoreactivity Following Chronic HypoxiaR01HL088192 · NHLBI · UNIVERSITY OF NEW MEXICO · PI RESTA, THOMAS C · 2008 to 2012
$1.9M
Vascular Smooth Muscle Signaling in Intermittent Hypoxia-Induced Pulmonary HypertensionR01HL132883 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 2016 to 2019
$1.5M
Endothelial BK Channels and Vasoreactivity Following Chronic HypoxiaR01HL095640 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI WALKER, BENJIMEN R · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL058124NHLBI NIH HHS R01 HL088192NHLBI NIH HHS R01 HL095640NHLBI NIH HHS R01 HL132883
6 · The paper itself

Abstract

Endothelial dysfunction in chronic hypoxia (CH)-induced pulmonary hypertension is characterized by reduced store-operated Ca

Indexed as

Calcium SignalingAnimalsArterial PressureBenzodioxolesCalcium Channel BlockersCell MembraneCells, CulturedCholesterolChromonesChronic DiseaseDisease Models, AnimalDown-RegulationEndothelial CellsHypoxiaMaleORAI1 ProteinAnCoA4 compoundBenzodioxolesCalcium Channel BlockersCholesterolChromonesORAI1 ProteinOrai1 protein, ratStim1 protein, ratStromal Interaction Molecule 1pulmonary hypertensionstore-operated calcium entrystromal interaction molecule 1

Identifiers

PMID29101179
PMCPMC5867657
OpenAlexW2766295933

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.