Evidence map›Paper›PMID 29101681›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2017

Patient Preferences for Attributes of Type 2 Diabetes Mellitus Medications in Germany and Spain: An Online Discrete-Choice Experiment Survey.

Carol Mansfield, Mirko V Sikirica, Amy Pugh, Christine M Poulos, Victoria Unmuessig, Raul Morano, Alan A Martin

Open access · goldAbstract read
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Treatment Preferences for Novel Type 2 Diabetes Oral Medications: Insights from the Asian Diabetes Patient Preference Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
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  7. Perspectives and Preferences of People with Type 2 Diabetes for the Attributes of Weekly Insulin.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
  8. Article
  9. Understanding the struggle: Unique challenges of adherence in male diabetic patients in Tshwane.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
    Article
  10. Article
  11. Outcomes and Attributes Patients Value When Choosing Glucose-Lowering Medications: A Mixed-Methods Study.Clinical diabetes : a publication of the American Diabetes Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Carol MansfieldRTI Health Solutions, Research Triangle Park, NC, USA.
Mirko V SikiricaGlaxoSmithKline, Collegeville, PA, USA. Mirko.x.sikirica@gsk.com.
Amy PughRTI Health Solutions, Research Triangle Park, NC, USA.
Christine M PoulosRTI Health Solutions, Research Triangle Park, NC, USA.
Victoria UnmuessigGlaxoSmithKline, Munich, Germany.
Raul MoranoGlaxoSmithKline, Madrid, Spain.
Alan A MartinGlaxoSmithKline, Brentford, UK.
RTI Health Solutions · USGlaxoSmithKline (Germany) · DEGlaxoSmithKline (Spain) · ESGlaxoSmithKline (United Kingdom) · GBGlaxoSmithKline (United States) · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnderstanding patient preferences for attributes of type 2 diabetes mellitus (T2DM) medications may help explain how the attributes differentially affect patient perceptions and behaviors. In this survey, we quantified the relative preferences among patients in Germany and Spain in separate analyses.

methodsA stated-preference, discrete-choice experiment (DCE) survey was designed to elicit preferences for T2DM treatment attributes among patients with self-reported T2DM and who reported being prescribed T2DM medication for > 2 years. Patients recruited from an online national consumer panel completed an online survey. The survey presented choices between eight pairs of hypothetical T2DM treatments defined by seven attributes: chance of reaching target hemoglobin A1c (HbA1c) level; reduced risk of serious heart attack or stroke; frequency of hypoglycemia; risk of gastrointestinal (GI) problems; weight change; mode of administration (oral or injectable); dosing frequency. Data were analyzed using random-parameters logit. Minimum acceptable benefit (MAB) was defined as the minimum increase in the probability of reaching target HbA1c for which respondents would accept less desirable levels of other attributes.

resultsIn Germany and Spain, 474 and 401 respondents completed the survey, respectively. DCE analysis showed that risk of GI problems was most important to German respondents. MAB analysis found that respondents would require a 56 percentage point increase in the probability of reaching their HbA1c target to offset a change from 0% to 30% risk of GI problems. For Spanish respondents, mode of administration was the most important attribute. These respondents would require a 59 percentage point increase in the probability of reaching their HbA1c target to offset moving from oral to injectable medications.

conclusionsRespondents in Germany and Spain were willing to trade efficacy for improvements in side effects and mode of administration. Given the variety of T2DM medications currently available, the results suggest that careful discussion about patient preferences could help improve patient satisfaction with T2DM treatment.

Indexed as

DiabetesDiscrete-choice experimentGermanyGlucose controlPatient preferencesSpainType 2 diabetes mellitus

Identifiers

PMID29101681
PMCPMC5688991
OpenAlexW2765781150

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.