Evidence map›Paper›PMID 29106545›Full record

GuidelineCardiovascular research2018

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology.

Joost Petrus Gerardus Sluijter, Sean Michael Davidson, Chantal M Boulanger, Edit Iren Buzás, Dominique Paschalis Victor de Kleijn, Felix Benedikt Engel, Zoltán Giricz, Derek J Hausenloy, Raj Kishore, Sandrine Lecour and 10 more

Abstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Cardiovascular research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Guideline
  5. Review
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  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Clinical Applications of Extracellular Vesicles: Promises and Pitfalls.International journal of molecular sciences · 2026
    Review
  14. Review
  15. Review
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  17. Article
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  19. Article
  20. Article

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Joost Petrus Gerardus SluijterExperimental Cardiology Laboratory, UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, University Utrecht, 3508GA Utrecht, The Netherlands.
Sean Michael DavidsonThe Hatter Cardiovascular Institute, University College London, London, UK.
Chantal M BoulangerINSERM UMR-S 970, Paris Cardiovascular Research Center-PARCC, Paris, France.
Edit Iren BuzásDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Dominique Paschalis Victor de KleijnDepartment of Vascular Surgery, UMC Utrecht, Utrecht University, Utrecht, the Netherlands.
Felix Benedikt EngelExperimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Zoltán GiriczDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
Derek J HausenloyCardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857.
Raj KishoreDepartment of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Sandrine LecourHatter Institute for Cardiovascular Research in Africa and Lionel Opie Preclinical Imaging Core Facility, Faculty of Health Sciences, University of Cape Town, South Africa.
Jonathan LeorNeufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel Hashomer, Israel; Tamman Cardiovascular Research Institute, Heart Center, Sheba Medical Center, Tel Hashomer, Israel.
Rosalinda MadonnaCenter of Aging Science and Regenerative Medicine, CESI-Met and Institute of Cardiology, "G. D'Annunzio" University, Chieti-Pescara, Chieti, Italy.
Cinzia PerrinoDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Fabrice PrunierInstitut Mitovasc, CHU d'Angers, Université d'Angers, Angers, France.
Susmita SahooCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ray Michel SchiffelersLaboratory Clinical Chemistry and Hematology Division, University Medical Center Utrecht, Utrecht, The Netherlands.
Rainer SchulzInstitute of Physiology, Justus-Liebig University of Giessen, Aulweg 129, 35392, Giessen, Germany.
Linda Wilhelmina Van LaakeDivision Heart and Lungs, and Hubrecht Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Kirsti YtrehusCardiovascular Research Group, Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway.
Péter FerdinandyDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary and.

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Walter J. Koch · 2017 to 2026
$21.0M
TNF mRNA stability and restenosisR01HL091983 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2009 to 2022
$5.3M
Pluripotent cell-derived exosomes as mediators of myocardial regenerationR01HL126186 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2015 to 2018
$1.6M
British Heart Foundation FS/10/039/28270British Heart Foundation PG/16/85/32471Medical Research Council MR/K002066/1NHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL091983NHLBI NIH HHS R01 HL126186
6 · The paper itself

Abstract

Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.

Indexed as

Diagnostic Techniques, CardiovascularAnimalsBiomarkersCardiologyCell- and Tissue-Based TherapyCell-Derived MicroparticlesCell FractionationConsensusExosomesHumansMyocardial IschemiaPredictive Value of TestsBiomarkersCardioprotectionCo-morbiditiesExosomesExtracellular vesiclesHeart failureIschaemiaMicrovesiclesPostconditioningPreconditioningRegenerative medicineRemote conditioningReperfusion

Identifiers

PMID29106545
PMCPMC5852624

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.