Trial reportThe Journal of clinical endocrinology and metabolism2017
Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory.
Trial report in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Three Doses of Vitamin D and Cognitive Outcomes in Older Women: A Double-Blind Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Gender differences and psychosocial stress in upper respiratory tract infections: insights from healthy and hematological cancer cohorts.BMC public health · 2026Article
- Neurokinin Antagonists to Treat Vasomotor Symptoms-Possible Implications for Long-Term Health and Disease.Journal of clinical medicine · 2025Article
- Association between chronic stress-related amygdala metabolic activity and lymph node metastasis in endometrial cancer.Scientific reports · 2024Article
- Impact of hormonal contraceptives on sex differences in fear conditioning and fear extinction in PTSD.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Article
- Women's Depressive Symptoms during the COVID-19 Pandemic: The Role of Pregnancy.International journal of environmental research and public health · 2021Article
- Estrogen, brain structure, and cognition in postmenopausal women.Human brain mapping · 2021Article
- The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.Journal of inflammation research · 2021Article
- Potential mechanisms linking psychological stress to bone health.International journal of medical sciences · 2021Review
- Brain activity during a post-stress working memory task differs between the hormone-present and hormone-absent phase of hormonal contraception.Neurobiology of stress · 2020Article
- Salivary Cortisol, Subjective Stress and Quality of Sleep Among Female Healthcare Professionals.Journal of multidisciplinary healthcare · 2020Article
- The Role of Cognitive Control in Age-Related Changes in Well-Being.Frontiers in aging neuroscience · 2020Article
- Sex Differences in Vulnerability and Resilience to Stress Across the Life Span.Biological psychiatry · 2019Review
- Effects of hormonal contraceptive phase and progestin generation on stress-induced cortisol and progesterone release.Neurobiology of stress · 2019Article
- Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions.Frontiers in psychiatry · 2019Review
- Postmenopausal hormone treatment alters neural pathways but does not improve verbal cognitive function.Menopause (New York, N.Y.) · 2018Article
- Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling.Journal of the American Heart Association · 2018Article
- Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.Endocrinology · 2018Article
- Steroid Hormones and Their Action in Women's Brains: The Importance of Hormonal Balance.Frontiers in public health · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Context: Postmenopausal estradiol therapy (ET) can reduce the stress response. However, it remains unclear whether such reductions can mitigate effects of stress on cognition. Objective: Investigate effects of ET on cortisol response to a physical stressor, cold pressor test (CPT), and whether ET attenuates stress effects on working memory. Design: Women completed the CPT or control condition across two sessions and subsequently completed a sentence span task. Setting: General community: Participants were recruited from the Early vs Late Intervention Trial with Estradiol (ELITE). Participants: ELITE participants (mean age = 66, standard deviation age = 6.8) in this study did not suffer from any major chronic illness or use medications known to affect the stress response or cognition. Interventions: Participants had received a median of randomized 4.7 years of estradiol (n = 21) or placebo (n = 21) treatment at time of participation in this study. Main Outcome Measures: Salivary cortisol and sentence span task performance. Results: Women assigned to estradiol exhibited blunted cortisol responses to CPT compared with placebo (P = 0.017) and lesser negative effects of stress on working memory (P = 0.048). Conclusions: We present evidence suggesting ET may protect certain types of cognition in the presence of stress. Such estrogenic protection against stress hormone exposure may prove beneficial to both cognition and the neural circuitry that maintains and propagates cognitive faculties.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.