Evidence map›Paper›PMID 29107453›Full record

ArticleJournal of diabetes and its complications2018

Longitudinal trends and predictors of statin use among patients with diabetes.

Meghan B Brennan, Elbert S Huang, Jennifer M Lobo, Hyojung Kang, Marylou Guihan, Anirban Basu, Min-Woong Sohn

Abstract read
In one paragraph

Article in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Fenofibrate and Diabetic Retinopathy.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Mortality risk reduction differs according to bisphosphonate class: a 15-year observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Observational
  9. Prescribing statins among patients with type 2 diabetes: The clinical gap between the guidelines and practice.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meghan B BrennanDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. Electronic address: mbbrennan@medicine.wisc.edu.
Elbert S HuangDepartment of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: ehuang@medicine.bsd.uchicago.edu.
Jennifer M LoboDepartment of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address: jem4yb@eservices.virginia.edu.
Hyojung KangDepartment of Systems and Information Engineering, School of Engineering, University of Virginia, Charlottesville, VA, USA. Electronic address: hk7z@virginia.edu.
Marylou GuihanCenter of Innovation for Complex Chronic Healthcare, Hines VA Hospital, Hines, IL, USA; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: marylou.guihan@va.gov.
Anirban BasuDepartments of Biostatistics and Health Services, School of Public Health, University of Washington, Seattle, WA, USA. Electronic address: basua@uw.edu.
Min-Woong SohnDepartment of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address: msohn@virginia.edu.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI Arshiya Ahmed Baig · 2011 to 2026
$10.0M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Comparative Effectiveness of Dynamic Patterns of Glucose Lowering TherapiesR01HS018542 · AHRQ · UNIVERSITY OF CHICAGO · PI HUANG, ELBERT S. · 2012 to 2015
$1.3M
Research and Mentorship in Medical Decision Making in DiabetesK24DK105340 · NIDDK · UNIVERSITY OF CHICAGO · PI HUANG, ELBERT S. · 2015 to 2019
$884k
AHRQ HHS R01 HS018542NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427NIDDK NIH HHS K24 DK105340NIDDK NIH HHS P30 DK092949
6 · The paper itself

Abstract

aimStatins reduce morbidity and mortality among patients with diabetes, but their use remains suboptimal. Understanding trends in statin use may inform strategies for improvement.

methodsWe enrolled a national, retrospective cohort of 899,664 veterans aged≥40years with diabetes in 2003. We followed them through 2011, dividing the nine-year follow-up into 90-day periods. For each period, we determined statin use, defined as possession of ≥30-day supply. We examine factors associated with statin uptake among baseline non-users with a multivariate model.

resultsBaseline prevalence of statin use was 43%, increased by 1.8% per period (p for trend<0.001), and reached a maximum of ~59%. Statin use among non-Hispanic racial/ethnic minorities lagged behind their white counterparts. Among baseline non-users, statin use was 9% after Year 1 and reached 36% by Year 9. Factors associated with statin uptake included use of hypoglycemic agents, HbA1c between 7 and 8.9% (53-74mmol/mol), hypertension, heart failure, peripheral vascular disease, and Hispanic ethnicity.

conclusionStatin use is slowly increasing among patients with diabetes, and at varying rates within subgroups of this population. Policies that prioritize these subgroups for statin promotion may help guide future, intervention-based research to increase compliance with current guidelines.

Indexed as

AgedCardiovascular DiseasesComorbidityDiabetes MellitusDiabetic AngiopathiesEthnicityFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLongitudinal StudiesMaleMiddle AgedPrevalenceRacial GroupsRetrospective StudiesHydroxymethylglutaryl-CoA Reductase InhibitorsCholesterol treatment guidelinesDiabetesHMG-CoA reductase inhibitorsRacial disparitiesTemporal trends

Identifiers

PMID29107453
PMCPMC5806700

What Socratic holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.