Evidence map›Paper›PMID 29109462›Full record

ArticleScientific reports2017

Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser.

Yan Li, Joseph Jing, Emon Heidari, Jiang Zhu, Yueqiao Qu, Zhongping Chen

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  4. Imaging theJournal of biomedical optics · 2025
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  7. Multiple scattering suppression forBiomedical optics express · 2024
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  10. Review
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  13. Article
  14. Ultrahigh-sensitive optical coherence elastography.Light, science & applications · 2020
    Article
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yan LiBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA, 92617, USA.
Joseph JingBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA, 92617, USA.ORCID 0000-0002-1283-3232
Emon HeidariBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA, 92617, USA.
Jiang ZhuBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA, 92617, USA.ORCID 0000-0002-2601-4967
Yueqiao QuBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA, 92617, USA.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA, 92617, USA. z2chen@uci.edu.
University of California, Irvine · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Elastographic Imaging of the Retina/Choroid in Age-Related Macular DegenerationR01EY021529 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, ZHONGPING, SILVERMAN, RONALD H · 2012 to 2015
$1.4M
NEI NIH HHS R01 EY021529NEI NIH HHS R01 EY026091NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01 HL127271NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

The main cause of acute coronary events, such as thrombosis, is the rupture of atherosclerotic plaques. Typical intravascular optical coherence tomography (IVOCT) imaging systems that utilize a 1.3 μm swept source laser are often used for identifying fibrous cap thickness of plaques, yet cannot provide adequate depth penetration to resolve the size of the lipid pool. Here, we present a novel  IVOCT system with a 1.7 μm center wavelength swept light source that can readily penetrate deeper into the tissue because of the longer wavelength and allows for better identification of plaques due to the lipid absorption spectrum at 1.7 μm. Using this system, we have imaged a human coronary artery to evaluate the performance of the novel OCT system and verified the results by hematoxylin and eosin (H&E) histology. The significantly improved imaging depth and better identification sensitivity suggest that the 1.7 μm OCT system holds great potential  that can be further translated for in-vivo applications of atherosclerosis characterization.

Indexed as

LasersCoronary Artery DiseaseCoronary VesselsEndoscopesEquipment DesignHumansPhantoms, ImagingPlaque, AtheroscleroticSensitivity and SpecificityTomography, Optical Coherence

Identifiers

PMID29109462
PMCPMC5674044
OpenAlexW2765154045

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.