ArticleMolecular medicine reports2018
Aconitine induces apoptosis in H9c2 cardiac cells via mitochondria‑mediated pathway.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity.Frontiers in pharmacology · 2022Pooled it
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- Cardiovascular protection of YiyiFuzi powder and the potential mechanisms through modulating mitochondria-endoplasmic reticulum interactions.Frontiers in pharmacology · 2024Review
- Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms.Frontiers in chemistry · 2024Review
- Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Efficacy analysis and research progress of complementary and alternative medicines in the adjuvant treatment of COVID-19.Journal of biomedical science · 2023Review
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- Ginsenoside RgChinese journal of integrative medicine · 2022Article
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- N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Aconitine induces brain tissue damage by increasing the permeability of the cerebral blood-brain barrier and over-activating endoplasmic reticulum stress.American journal of translational research · 2022Article
- Hematological and Histopathological Effects of Subacute Aconitine Poisoning in Mouse.Frontiers in veterinary science · 2022Article
- Processed lateral root ofFrontiers in pharmacology · 2022Review
- Identification of downstream targets and signaling pathways of long non-coding RNA NR_002794 in human trophoblast cells.Bioengineered · 2021Article
- Anticancer Activity ofIranian journal of pharmaceutical research : IJPR · 2021Article
- Aconitine Induces TRPV2-Mediated CaEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial FunctionFrontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aconitine, a diterpenoid alkaloids derived from Aconitum plants, is widely employed to treat various diseases. The aim of the present study was to investigate the apoptotic effect of aconitine in H9c2 cardiac cells. H9c2 cell apoptosis induced by aconitine was detected by a Cell Counting kit‑8 assay, DAPI staining, Annexin V‑FITC/propidium iodide double staining and western blotting. The effects of aconitine on reactive oxygen species levels and mitochondrial membrane potential were confirmed by fluorescence microscopy and flow cytometry. In addition, ATP contents were determined using a ATP‑dependent bioluminescence assay kit. The levels of peroxisome proliferator activated receptor γ co‑activator 1α (PGC‑1α) expression and apoptosis‑associated proteins including Caspase‑3, B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and Cytochrome c were also assessed. Taken together, the results indicated that aconitine may inhibit cell viability, decrease PGC‑1α expression, induce mitochondrial dysfunctions, upregulate Cytochrome c, Bax and Caspase‑3, and downregulate Bcl‑2, suggesting that aconitine may induce apoptosis through mitochondria‑mediated signaling pathways in H9c2 cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.