ArticleAmerican journal of translational research2017
Topical insulin accelerates cutaneous wound healing in insulin-resistant diabetic rats.
Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Insights Into Macrophage Polarization and M1/M2 Balance in Diabetic Foot Ulcers.Journal of diabetes · 2026Review
- Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.Nature communications · 2025Article
- M2 macrophage-polarized anti-inflammatory microneedle patch for accelerating biofilm-infected diabetic wound healing via modulating the insulin pathway.Journal of nanobiotechnology · 2024Article
- Diabetes and Osteoarthritis: Exploring the Interactions and Therapeutic Implications of Insulin, Metformin, and GLP-1-Based Interventions.Biomedicines · 2024Review
- The Use of Fast-Acting Insulin Topical Solution on Skin to Promote Surgical Wound Healing in Cats.Animals : an open access journal from MDPI · 2024Article
- Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis.Frontiers in nutrition · 2024Article
- Design, Development andRecent advances in drug delivery and formulation · 2024Article
- Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing.Journal of biomedical science · 2023Review
- Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis.Frontiers in cell and developmental biology · 2023Review
- Guiding stem cells for cutaneous repair.Current research in pharmacology and drug discovery · 2023Review
- Rheumatoid Arthritis Treatment Options and Type 2 Diabetes: Unravelling the Association.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2022Article
- Liver macrophages and inflammation in physiology and physiopathology of non-alcoholic fatty liver disease.The FEBS journal · 2022Review
- Article
- New insights into aging-associated characteristics of female subcutaneous adipose tissue through integrative analysis of multi-omics data.Bioengineered · 2022Article
- Controlled Release of the α-Tocopherol-Derived Metabolite α-13'-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing.Nanomaterials (Basel, Switzerland) · 2021Article
- Insulin, but Not Metformin, Supports Wound Healing Process in Rats with Streptozotocin-Induced Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Insulin Signaling in Arthritis.Frontiers in immunology · 2021Review
- Metabolite profiling and wound-healing activity ofJournal of traditional and complementary medicine · 2020Article
- The efficacy of topical insulin application on rat model with burn wounds treated with adipose-derived stem cells.International journal of burns and trauma · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin signaling defects could lead to insulin resistance in insulin target organs: typically, in the muscler, liver, and adipose tissue. We have observed that insulin accelerated diabetic wound healing in our previous works; to further elucidate the mechanism, we investigated the expression and activation of insulin and insulin-like growth factor (IGF)-1 signaling, compared insulin sensitivity in skin tissue with that in liver tissue, and also observed the regulation of insulin on inflammatory response of wounds during the healing process. We found lower expression of insulin receptor, phos-AKT, IGF-1 in type II diabetic rat skin compared with that in normal rat skin. However, the level of phos-AKT in diabetic rat skin remarkably increased after systemic insulin injection, whereas no significant change of phos-AKT was observed in liver upon insulin stimulation. In insulin-treated wounds, we detected a significant increase in insulin signaling proteins and growth factor, as well as the phosphorylated insulin receptor substrate-1 and AKT. The increased Glut1 protein level and translocation of Glut1 from cytosol to cell membrane of the basal epidermal cells were also observed after insulin application. Insulin-treated wounds showed advanced infiltration and resolution of macrophages and a change pattern similar to that of inflammatory mediators, including TNF-α and IL-6. Our findings support that insulin is a valid agent for diabetic wound healing because of its effect on ameliorating defective insulin action and regulating inflammation response. Our results indicate the presence of subtle insulin responsiveness in diabetic skin tissue, regardless of the presence of impaired insulin sensitivity, which could be the cellular and molecular mechanism of insulin accelerating diabetic wound healing.
Indexed as
Identifiers
29118927PMC5666074W2991082109What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.