Evidence map›Paper›PMID 29122145›Full record

SynthesisGeneral hospital psychiatry2017

Exercise effects on depression: Possible neural mechanisms.

Swathi Gujral, Howard Aizenstein, Charles F Reynolds, Meryl A Butters, Kirk I Erickson

2 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in General hospital psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 148 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05985096 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effects of Virtual Reality Education on Balance, Depression, Anxiety and Stress Parameters in Healthy Young Individuals

TypeinterventionalSponsorOrdu UniversityRan2023 to 2024Enrolled60ConditionsAnxiety, Depression, Stress, BalancedArmsVirtual reality group
NCT06775548 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Effects of Exercises and Vitamins on Oxidative Stress & Inflammatory Markers Among Patients with Depression

TypeinterventionalSponsorZiauddin UniversityRan2024 to 2025Enrolled116ConditionsDepression DisordersArmsAerobic Exercises + Vitamin E, Resistance Exercises + Vitamin E, Aerobic Exercises + Vitamin D, Resistance Exercises + Vitamin D
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  9. Exercise training and depression and anxiety in musculoskeletal pain patients: a meta-analysis of randomized control trials.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2023
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  18. Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Swathi GujralUniversity of Pittsburgh, Department of Psychology, United States; Center for Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, United States. Electronic address: swh24@pitt.edu.
Howard AizensteinWestern Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States.
Charles F ReynoldsWestern Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States.
Meryl A ButtersWestern Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States.
Kirk I EricksonUniversity of Pittsburgh, Department of Psychology, United States; Center for Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, United States.

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 2011 to 2015
$8.3M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
NIA NIH HHS P30 AG024827NIA NIH HHS P50 AG005133NIDDK NIH HHS R01 DK095172NIMH NIH HHS P30 MH090333
6 · The paper itself

Abstract

Depression is a syndrome of stress- and emotion-dysregulation, involving compromised structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric reductions in the hippocampus, anterior cingulate cortex, prefrontal cortex, striatum, and amygdala, as well as compromised white matter integrity are frequently observed in depressed adults. Exercise has shown promise as an effective treatment for depression, but few studies have attempted to characterize or identify the neural mechanisms of these effects. In this review, we examined the overlap between structural brain abnormalities in depression and the effects of exercise on brain structure in adults, to highlight possible neural mechanisms that may mediate the positive effects of exercise on depressive symptoms. The prefrontal cortex, anterior cingulate cortex, hippocampus, and corpus callosum emerged as structural neural markers that may serve as targets for exercise-based treatments for depression. These findings highlight the need for randomized exercise interventions to test these proposed neurobiological mechanisms of exercise on depression.

Indexed as

AdultAgedAged, 80 and overBrainDepressionDepressive DisorderExercise TherapyHumansMiddle AgedYoung AdultDepressionExerciseGray matterMRIWhite matter

Identifiers

PMID29122145
PMCPMC6437683

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.