Evidence mapPaperPMID 29122890Full record

ArticleJournal of lipid research2018

microRNA-30c reduces plasma cholesterol in homozygous familial hypercholesterolemic and type 2 diabetic mouse models.

Sara Irani, Jahangir Iqbal, W James Antoni, Laraib Ijaz, M Mahmood Hussain

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  3. Article
  4. Advances in the Regulation of Lipid Metabolism by Non-Coding RNAs.Animals : an open access journal from MDPI · 2025
    Review
  5. Review
  6. Emerging Role of MicroRNA-30c in Neurological Disorders.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
  9. MicroRNA regulation of cholesterol metabolism.Annals of the New York Academy of Sciences · 2021
    Review
  10. MicroRNA-mediated regulation of glucose and lipid metabolism.Nature reviews. Molecular cell biology · 2021
    Review
  11. MicroRNAs, Parkinson's Disease, and Diabetes Mellitus.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sara IraniSchool of Graduate Studies, Molecular and Cell Biology Program The State University of New York Downstate Medical Center, Brooklyn, NY.
Jahangir IqbalDepartment of Cell Biology, The State University of New York Downstate Medical Center, Brooklyn, NY.
W James AntoniNew York University Winthrop Hospital, Mineola, NY.
Laraib IjazNew York University Winthrop Hospital, Mineola, NY.
M Mahmood HussainDepartment of Cell Biology, The State University of New York Downstate Medical Center, Brooklyn, NY Mhussain@nyuwinthrop.org.
Winthrop-University Hospital · USNew York University · USState University of New York · US

Funding

BLRD VA I01 BX001728NIDDK NIH HHS R56 DK046900
6 · The paper itself

Abstract

High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induced hypercholesterolemia and atherosclerosis in C57BL/6J and

Indexed as

AnimalsCholesterolDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Disease Models, AnimalHumansHypercholesterolemiaMiceMice, Inbred C57BLMice, KnockoutMice, ObeseMicroRNAsReceptors, LDLCholesterolMicroRNAsMIRN30b microRNA, humanReceptors, LDLdiabeteslipidsmicro-ribonucleic acid-30csteatosis

Identifiers

PMID29122890
PMCPMC5748505
OpenAlexW2781843221

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.