Evidence map›Paper›PMID 29129751›Full record

ArticleRespiratory physiology & neurobiology2018

Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.

Leszek Kubin, Graziella L Mann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Impact of Serotonergic 5HTInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leszek KubinDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6046, USA. Electronic address: lkubin@vet.upenn.edu.
Graziella L MannDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6046, USA.
University of Pennsylvania · US

Funding

PREMOTOR CONTROL OF UPPER AIRWAY AND REM SLEEP ATONIAR01HL047600 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KUBIN, LESZEK K · 1992 to 2018
$5.6M
Upper airway control during disrupted and misaligned sleepR01HL116508 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KUBIN, LESZEK K · 2013 to 2015
$1.2M
NHLBI NIH HHS R01 HL047600NHLBI NIH HHS R01 HL116508
6 · The paper itself

Abstract

In obstructive sleep apnea patients, contraction of lingual muscles protects the pharyngeal airway from collapse. Hypoglossal (XII) motoneurons innervate the muscles of the tongue and are themselves under wake-related excitatory drives, including that mediated by serotonin (5-HT). Estimates of endogenous 5-HT activation vary among different studies. We tested whether endogenous drive mediated by 5-HT is present in rat XII motoneurons when measured during the active period of the circadian cycle. We monitored sleep-wake states and lingual and nuchal electromyograms (EMGs) while perfusing the XII nucleus with a vehicle or a 5-HT

Indexed as

Analysis of VarianceAnimalsBrain StemCerebral CortexCircadian RhythmElectroencephalographyElectromyographyHypoglossal NerveMaleMianserinMotor NeuronsMuscle, SkeletalRatsRats, Sprague-DawleySerotoninSerotonin AntagonistsMianserinSerotoninSerotonin AntagonistsMianserinSerotonin receptorsSleepSleep apneaTongueUpper airway

Identifiers

PMID29129751
PMCPMC5747974
OpenAlexW2767868053

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.