Evidence map›Paper›PMID 29130758›Full record

ReviewDrug delivery2017

Proniosomes derived niosomes: recent advancements in drug delivery and targeting.

Maryam Khatoon, Kifayat Ullah Shah, Fakhar Ud Din, Shefaat Ullah Shah, Asim Ur Rehman, Naz Dilawar, Ahmad Nawaz Khan

Open access · goldAbstract readReview
In one paragraph

Review in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.

  1. Pooled it
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  13. Nanoparticle tools for maximizing oral drug delivery.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Review
  14. Article
  15. Bioadhesive hybrid system of niosomes and pH sensitiveSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maryam Khatoona Department of Pharmacy , Quaid-e-Azam University , Islamabad , Pakistan.
Kifayat Ullah Shaha Department of Pharmacy , Quaid-e-Azam University , Islamabad , Pakistan.ORCID http://orcid.org/0000-0003-4061-8174
Fakhar Ud Dina Department of Pharmacy , Quaid-e-Azam University , Islamabad , Pakistan.
Shefaat Ullah Shahb Department of Pharmaceutics, Faculty of Pharmacy , Gomal University , D.I. Khan , Pakistan.ORCID http://orcid.org/0000-0003-3271-2806
Asim Ur Rehmana Department of Pharmacy , Quaid-e-Azam University , Islamabad , Pakistan.
Naz Dilawara Department of Pharmacy , Quaid-e-Azam University , Islamabad , Pakistan.
Ahmad Nawaz Khanc School of Chemical and materials Engineering , National University of Sciences and Technology , Islamabad , Pakistan.
Quaid-i-Azam University · PKGomal University · PKNational University of Sciences and Technology · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vesicular drug delivery systems have gained wide attention in the field of nanotechnology. Among them proniosomes become the superior over other vesicular carriers. Proniosomes are dry formulations of water soluble nonionic surfactant coated carrier system which immediately forms niosomes upon hydration. They have the capability to overcome the instability problems associated with niosomes and liposomes and have the potential to improve solubility, bioavailability, and absorption of various drugs. Furthermore, they offer versatile drug delivery concept for enormous number of hydrophilic and hydrophobic drugs. They have the potential to deliver drugs effectively through different routes at specific site of action to achieve controlled release action and reduce toxic effects associated with drugs. This review discusses the general preparation techniques of proniosomes and mainly focus on the applications of proniosomes in drug delivery and targeting. Moreover, this review demonstrates critical appraisal of the literature for proniosomes. Additionally, this review extensively explains the potential of proniosomes in delivering drugs via different routes, such as oral, parenteral, dermal and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. Finally, the comparison of proniosomes with niosomes manifests the clear distinction between them. Moreover, proniosomes need to be explored for proteins and peptide delivery and in the field of nutraceuticals and develop pilot plant scale up studies to investigate them in industrial set up.

Indexed as

Administration, CutaneousAnimalsChemistry, PharmaceuticalDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsHumansLiposomesDelayed-Action PreparationsDrug CarriersLiposomesadvancementsdrug deliveryhydrationniosomesProniosomestargetingtransdermal

Identifiers

PMID29130758
PMCPMC8812579
OpenAlexW2769745398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.