Evidence map›Paper›PMID 29133867›Full record

ArticleNature communications2017

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.

Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J Wild, Ian J Frew

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Renal cystic disease in tuberous sclerosis complex.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  8. Review
  9. PKHCells · 2020
    Article
  10. The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review.Journal of experimental & clinical cancer research : CR · 2019
    Review
  11. Review
  12. miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma.Laboratory investigation; a journal of technical methods and pathology · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ana Filipa GonçalvesInstitute of Physiology, University of Zurich, 8057, Zurich, Switzerland.
Mojca AdlesicInstitute of Physiology, University of Zurich, 8057, Zurich, Switzerland.
Simone BrandtDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, Switzerland.
Tomas HejhalInstitute of Physiology, University of Zurich, 8057, Zurich, Switzerland.
Sabine HarlanderInstitute of Physiology, University of Zurich, 8057, Zurich, Switzerland.
Lukas SommerInstitute of Anatomy, University of Zurich, 8057, Zurich, Switzerland.
Olga ShakhovaInstitute of Anatomy, University of Zurich, 8057, Zurich, Switzerland.
Peter J WildDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, Switzerland.
Ian J FrewInstitute of Physiology, University of Zurich, 8057, Zurich, Switzerland. ian.frew@uniklinik-freiburg.de.
University of Zurich · CHUniversity Hospital of Zurich · CHUniversity Medical Center Freiburg · DE

Funding

European Research Council 260316
6 · The paper itself

Abstract

Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an unidentified AML neoplastic stem cell. Biallelic inactivation of TSC2 or TSC1 is believed to represent the driving event in these tumours. Here we show that TSC2 knockdown transforms senescence-resistant cultured mouse and human renal epithelial cells into neoplastic stem cells that serially propagate renal AML-like tumours in mice. mTOR inhibitory therapy of mouse AML allografts mimics the clinical responses of human renal AMLs. Deletion of Tsc1 in mouse renal epithelia causes differentiation in vivo into cells expressing characteristic AML markers. Human renal AML and a renal AML cell line express proximal tubule markers. We describe the first mouse models of renal AML and provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells, uncovering an unexpected pathological differentiation plasticity of the proximal tubule.

Indexed as

AngiomyolipomaAnimalsCell DifferentiationEpithelial CellsHumansKidney NeoplasmsKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutMice, SCIDNeoplasm TransplantationNeoplastic Stem CellsRNA InterferenceRNA, Small InterferingSpheroids, CellularmTOR protein, mouseRNA, Small InterferingTOR Serine-Threonine KinasesTSC1 protein, humanTsc1 protein, mouseTSC2 protein, humanTsc2 protein, mouseTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTumor Suppressor Proteins

Identifiers

PMID29133867
PMCPMC5684212
OpenAlexW2767358767

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.