Evidence mapPaperPMID 29137450Full record

ReviewOncotarget2017

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials.

Helen J MacKay, Douglas A Levine, Victoria L Bae-Jump, Daphne W Bell, Jessica N McAlpine, Alessandro Santin, Gini F Fleming, David G Mutch, Kenneth P Nephew, Nicolas Wentzensen and 5 more

Open access · diamondAbstract readReview
In one paragraph

Review in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Beyond Obesity: The Rising Incidence and Mortality Rates of Uterine Corpus Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  4. Identification of a subset of microsatellite-stable endometrial carcinoma with high PD-L1 and CD8+ lymphocytes.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 3 countries.

Helen J MacKayDivision of Medical Oncology & Hematology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Douglas A LevineDivision of Gynecologic Cancer, Department of OB/GYN, NYU Langone Laura and Isaac Perlmutter Cancer Center, New York, NY, United States.
Victoria L Bae-JumpDivision of Gynecologic Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, CA, United States.
Daphne W BellReproductive Cancer Genetics Section, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute/NIH, MSC 8000, Bethesda, ML, United States.
Jessica N McAlpineUniversity of British Columbia & BC Cancer Agency, Division of Gynecologic Oncology, Vancouver, British Columbia, Canada.
Alessandro SantinDepartment of Gynecology, Obstetrics and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United States.
Gini F FlemingSection of Hematology-Oncology, Department of Medicine, The University of Chicago, Chicago, IL, United States.
David G MutchDepartment of Obstetrics & Gynecology, Washington University School of Medicine, St. Louis, MO, United States.
Kenneth P NephewMedical Sciences Program, Indiana University School of Medicine, Bloomington, IN, United States.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, ML, United States.
Paul J GoodfellowJames Comprehensive Cancer Center and The Department of Obstetrics and Gynecology, Ohio State University, Columbus, OH, United States.
Oliver DorigoDivision Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford, CA, United States.
Hans W NijmanDepartment of Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Russell BroaddusDepartment of Pathology, Unit 85, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Elise C KohnClinical Investigations Branch of The Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, ML, United States.
National Cancer Institute · USBC Cancer Agency · CAHealth Sciences Centre · CAIndiana University School of MedicineNational Human Genome Research Institute · USNYU Langone’s Laura and Isaac Perlmutter Cancer CenterThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe University of Texas MD Anderson Cancer Center · USUNC Lineberger Comprehensive Cancer CenterUniversity Medical Center Groningen · NLUniversity of Chicago · USWashington University in St. Louis · USYale University · US

Funding

Transgenic AnimalP30CA016058 · NCI · OHIO STATE UNIVERSITY · 1985 to 2025
$46.0M
Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
Hormone-Related CancersZIACP010126 · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · 2025 to 2025
$7.8M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016058NCI NIH HHS U10 CA180833
6 · The paper itself

Abstract

The incidence and mortality rates from endometrial cancer are increasing. There have been no new drugs approved for the treatment of endometrial cancer in decades. The National Cancer Institute, Gynecologic Cancer Steering Committee identified the integration of molecular and/or histologic stratification into endometrial cancer management as a top strategic priority. Based on this, they convened a group of experts to review the molecular data in this disease. Here we report on the actionable opportunities and therapeutic directions identified for incorporation into future clinical trials.

Indexed as

endometrial cancermolecular targets

Identifiers

PMID29137450
PMCPMC5663622
OpenAlexW2742714490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.