ArticleEpigenetics2017
The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific.
Article in Epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Maternal Smoking during Pregnancy, Smoking Initiation, and the Risk of Epilepsy in the UK Biobank.Neuroepidemiology · 2026Article
- Early-life exposure to cigarette smoke primes lung function and DNA methylation changes atAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Vaping and Lung Inflammation and Injury.Annual review of physiology · 2022Review
- Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells.Epigenetics & chromatin · 2021Article
- Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with AberrantInternational journal of molecular sciences · 2020Article
- Prenatal smoke exposure induces persistentEpigenetics · 2020Article
- Article
- Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring.International journal of molecular sciences · 2020Article
- Developmental origin and sex-specific risk for infections and immune diseases later in life.Seminars in immunopathology · 2019Review
- Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung.Clinical epigenetics · 2019Review
- Fermented corn-soybean meal elevated IGF1 levels in grower-finisher pigs.Journal of animal science · 2018Article
- Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism.International journal of molecular sciences · 2018Review
- Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.Scientific reports · 2018Article
- Abnormal Epigenetic Regulation of Immune System during Aging.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of prenatal smoke exposure (PSE) on DNA methylation has been demonstrated in blood samples from children of smoking mothers, but evidence for sex-dependent smoke-induced effects is limited. As the identified differentially methylated genes can be associated with developmental processes, and insulin-like growth factors (IGFs) play a critical role in prenatal tissue growth, we hypothesized that PSE induces fetal programming of Igf1r and Igf1. Using a mouse model of smoking during pregnancy, we show that PSE alters promoter methylation of Igf1r and Igf1 and deregulates their gene expression in lung and liver of fetal (E17.5) and neonatal (D3) mouse offspring. By further comparing female versus male, lung versus liver, or fetal versus neonatal time point, our results demonstrate that CpG site-specific aberrant methylation patterns sex-dependently vary per organ and time point. Moreover, PSE reduces gene expression of Igf1r and Igf1, dependent on organ, sex, and offspring's age. Our results indicate that PSE may be a source of organ-specific rather than general systemic fetal programming. This is exemplified here by gene promoter methylation and mRNA levels of Igf1r and Igf1, together with a sex- and organ-specific naturally established correlation of both parameters that is affected by prenatal smoke exposure. Moreover, the comparison of fetuses with neonates suggests a CpG site-dependent reversibility/persistence of PSE-induced differential methylation patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.