Evidence map›Paper›PMID 29176261›Full record

ArticleJournal of atherosclerosis and thrombosis2018

Reduced Vitamin D Receptor on Circulating Endothelial Progenitor Cells: A New Risk Factor of Coronary Artery Diseases.

Sidi Ai, Zhiqing He, Ru Ding, Feng Wu, Zhigang Huang, Jiamei Wang, Shuaibo Huang, Xianliang Dai, Jiayou Zhang, Jing Chen and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Vitamin D and Kawasaki disease.Frontiers in pharmacology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Effects of Early Intensive Insulin Therapy on Endothelial Progenitor Cells in Patients with Newly Diagnosed Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sidi AiDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Zhiqing HeDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Ru DingDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Feng WuDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Zhigang HuangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Jiamei WangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Shuaibo HuangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Xianliang DaiDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Jiayou ZhangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Jing ChenDepartment of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University.
Linlin LiuDepartment of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University.
Zonggui WuDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Chun LiangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University.
Shanghai Changzheng Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimEndothelial progenitor cells (EPCs) are shown to participate in the pathological processes of atherosclerosis. While Vitamin D and its receptor axis might exert some effects on EPCs' function. But their exact relationship with clinical patients is still elusive, which inspired us to explore the potential association of vitamin D receptor (VDR) expression on circulating EPCs and serum vitamin D levels among patients with coronary artery disease (CAD).

methodsTwo hundred patients with CAD after their admission to hospital and one hundred healthy controls were enrolled. Medical history data were retrieved and fresh blood samples were collected for flow cytometry analysis. VDR expressions on EPCs were evaluated according to the standardized protocol. Logistic regression analysis was used to investigate the potential risk factor of CAD.

resultsCAD patients were found to have lower log

conclusionA significant decrease of VDR expression on circulating EPCs was observed among CAD patients, particularly among those also with diabetes. VDR expression on EPCs was independently negatively correlated with HbA

Indexed as

BiomarkersCase-Control StudiesCells, CulturedChinaCoronary Artery DiseaseEndothelial Progenitor CellsFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisReceptors, CalcitriolRisk FactorsBiomarkersReceptors, CalcitriolVDR protein, humanCoronary artery diseaseDiabetesEndothelial progenitor cellsVitamin D receptor

Identifiers

PMID29176261
PMCPMC5945554
OpenAlexW2769754972

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.