Evidence map›Paper›PMID 29187281›Full record

ArticleBMB reports2018

HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter.

Xueliang Yang, Ming Han, Shunai Liu, Xiaoxue Yuan, Xiaojing Liu, Shenghu Feng, Li Zhou, Yaru Li, Hongping Lu, Jun Cheng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Xueliang YangDepartment of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Ming HanPeking University Ditan Teaching Hospital, Beijing 100015; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Shunai LiuBeijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Xiaoxue YuanBeijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Xiaojing LiuDepartment of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Shenghu FengPeking University Ditan Teaching Hospital, Beijing 100015; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Li ZhouPeking University Ditan Teaching Hospital, Beijing 100015; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
Yaru LiBeijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Hongping LuBeijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Jun ChengPeking University Ditan Teaching Hospital, Beijing 100015; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Shumei LinDepartment of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Beijing Ditan Hospital · CNCapital Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sterol regulatory element-binding protein-1c (SREBP1c) plays an important role in triglyceride (TG) homeostasis. Although our previous study showed that hepatitis C virus core-binding protein 6 (HCBP6) regulates SREBP1c expression to maintain intracellular TG homeostasis, the mechanism underlying this regulation is unclear. In the present study, we found that HCBP6 increased intracellular TG levels by upregulating SREBP1c expression. HCBP6 increased SREBP1c transcription by directly binding to the SREBP1c promoter (at the -139- to +359-bp region). Moreover, we observed that HCBP6 interacted with C/EBPβ-binding site in the SREBP1c promoter both in vitro and in vivo. These results indicate that HCBP6 upregulates human SREBP1c expression by binding to the C/EBPβ-binding site in the SREBP1c promoter. [BMB Reports 2018; 51(1): 33-38].

Indexed as

Binding SitesCCAAT-Enhancer-Binding Protein-betaGene SilencingHepacivirusHep G2 CellsHomeostasisHumansNon-alcoholic Fatty Liver DiseasePromoter Regions, GeneticRNA, Small InterferingSterol Regulatory Element Binding Protein 1Transcriptional ActivationTriglyceridesUp-RegulationViral Core ProteinsCCAAT-Enhancer-Binding Protein-betaRNA, Small InterferingSterol Regulatory Element Binding Protein 1TriglyceridesViral Core Proteins

Identifiers

PMID29187281
PMCPMC5796632
OpenAlexW2786532932

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.