Evidence map›Paper›PMID 29187576›Full record

ArticleMolecular biology of the cell2018

Host cell perforation by listeriolysin O (LLO) activates a Ca

Jonathan G T Lam, Stephen Vadia, Sarika Pathak-Sharma, Eric McLaughlin, Xiaoli Zhang, Joel Swanson, Stephanie Seveau

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Host-Cell-Dependent Roles of E-Cadherin inInternational journal of molecular sciences · 2023
    Article
  6. Genomic and pathogenicity islands ofFrontiers in molecular biosciences · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Host Lipid Rafts as the Gates forFrontiers in immunology · 2020
    Review
  15. Article
  16. Review
  17. Infection and immunity · 2019
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jonathan G T LamDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
Stephen VadiaDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.
Sarika Pathak-SharmaDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
Eric McLaughlinCenter for Biostatistics, The Ohio State University, Columbus, OH 43210.
Xiaoli ZhangCenter for Biostatistics, The Ohio State University, Columbus, OH 43210.
Joel SwansonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5624.
Stephanie SeveauDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210 seveau.1@osu.edu.
The Ohio State University · USThe Ohio State University Wexner Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

Multifaceted activity of listeriolysin O during host cell invasion by ListeriaR01AI107250 · NIAID · OHIO STATE UNIVERSITY · PI SEVEAU, STEPHANIE M M · 2014 to 2018
$1.9M
The Regulation of MacropinocytosisR01GM110215 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, JOEL A · 2014 to 2017
$1.3M
Interdisciplinary Program in Microbe-Host BiologyT32AI112542 · NIAID · OHIO STATE UNIVERSITY · PI JUSTICE, SHERYL S, WOZNIAK, DANIEL J · 2014 to 2018
$644k
NIAID NIH HHS R01 AI107250NIAID NIH HHS T32 AI112542NIGMS NIH HHS R01 GM110215
6 · The paper itself

Abstract

Host cell invasion is an indispensable step for a successful infection by intracellular pathogens. Recent studies identified pathogen-induced host cell plasma membrane perforation as a novel mechanism used by diverse pathogens (

Indexed as

Actin-Related Protein 2-3 ComplexActinsBacterial ProteinsBacterial ToxinsCell MembraneCytoplasmFluorescence Resonance Energy TransferHeat-Shock ProteinsHemolysin ProteinsHep G2 CellsHumansListeria monocytogenesListeriosisMembranesProtein Kinase CProteolysisActin-Related Protein 2-3 ComplexActinsBacterial ProteinsBacterial ToxinsHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesinternalin protein, BacteriaProtein Kinase Crac1 GTP-Binding Protein

Identifiers

PMID29187576
PMCPMC5996962
OpenAlexW2768237102

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.